Archives of the Turkish Society of Cardiology
In determining cut-off values for increased carotid intima-media thickness age should be considered [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-94770 | DOI: 10.5543/tkda.2018.94770

In determining cut-off values for increased carotid intima-media thickness age should be considered

Ayşe Selcan Koç1, Hilmi Erdem Sümbül2
1Department of Radiology, University of Health Sciences Adana Health Practice and Research Center, Adana, Turkey
2Department of Internal Medicine, University of Health Sciences Adana Health Practice and Research Center, Adana, Turkey


OBJECTIVE
Regardless of age and gender, the guidelines are considered to be >0.9 mm as the cut-off value for increased carotid intima-media thickness (C-IMT). In our study, we planned to investigate the effects of age and gender on C-IMT and cut-off values for C-IMT in different age groups.

METHODS
644 patients with a C-IMT measurement of at least 1 cardiovascular risk factor between 20-90 years of age were included. Common and internal C-IMT (CC-IMT and IC-IMT) measurements were obtained from carotid ultrasonography (USG). Patients, included in the study were divided into 5 groups as Group-I (20-40), Group-II (41-50), Group-III (51-60), Group-IV (61-70) and Group-V (>70).

RESULTS
CC-IMT and IC-IMT values significantly increased from Group-I to Group-V. Group I-II-II-IV-V showed median CC-IMT values of 0.70-0.70-0.75-0.75-0.85mm, respectively. IC-IMT median value was 0.60-0.65-0.70-0.70-0.80 mm, respectively. In all groups, the median CC-IMT value was found to be 50μm higher than the median IC-IMT value. Only CC-IMT values were significantly different in males (0.80±0.20 mm vs. 0.76±0.19 mm, p=0.020). Increased age, hypertension (HT), smoking, hyperlipidemia, systolic-diastolic blood pressures and body mass index were found to be associated with increased C-IMT. Increased C-IMT was independently associated with age and HT presence. It was found that age increases every-1 decade and the presence of HT determines the presence of increased C-IMT by 44% and 53%, respectively.

CONCLUSION
C-IMT significantly increases with age. For this reason, new age-appropriate cut-off values are needed for C-IMT. In addition, CC-IMT values are approximately 50μm higher than IC-IMT measurements in all age groups and CC-IMT should be reported in USG reports.

Keywords: Advanced age, carotid intima-media thickness; cut-off values.

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Corresponding Author: Ayşe Selcan Koç, Türkiye
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