Turk Kardiyol Dern Ars. Ahead of Print: TKDA-93762 | DOI: 10.5543/tkda.2018.93762
Lipid profile and atherogenic indices and their association with platelet indices in familial Mediterranean fever
, Muhammet Murat Çelik21
Department of Biochemistry, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey2
2Department of Internal Medicine, Mustafa Kemal University, Faculty of Medicine, Hatay, Turkey
OBJECTIVE In this study, we aimed to investigate lipid profiles and atherogenic indices and their association with platelet indices in familial Mediterranean fever (FMF) patients.
METHODS 63 FMF patients and 51 healthy individuals were included in this retrospective study. Inflammatory markers (including erythrocyte sedimentation rate, C-reactive protein, fibrinogen), platelet indices (including mean platelet volume, plateletcrit, platelet large cell ratio and platelet distribution width), lipid profiles (including total cholesterol, triglycerides, high density lipoprotein cholesterol, and low density lipoprotein cholesterol) levels were recorded. Also, atherogenic indices (atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castellis risk indices I and II (CRI I and II) were calculated using lipid parameters.
RESULTS In FMF patients, while AIP, AC, CRI I and II values were significantly higher than the healthy control group, high density lipoprotein cholesterol levels were significantly lower (all p<0.05). However, no significant difference was determined in terms of other studied parameters (all p>0.05). In male FMF patients, whereas AIP, AC, CRI I and II values were significantly higher than female FMF patients, platelet count, erythrocyte sedimentation rate and high density lipoprotein cholesterol levels were significantly lower (all p<0.05). Levels of C-reactive protein were negatively correlated with high density lipoprotein cholesterol (r=−0.275, p=0.032) and total cholesterol levels (r=−0.313, p=0.014) in FMF patients. High density lipoprotein cholesterol levels were negatively correlated with disease duration (r=−0.269, p=0.049).
CONCLUSION Using of atherogenic indices may be recommended to identify patients with increased risk of the atherosclerotic cardiovascular disease in FMF, especially in male patients.
Familial Mediterranean fever, atherogenic index of plasma, mean platelet volume, atherosclerosis.
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Corresponding Author: Gökhan Çakırca, Türkiye