Archives of the Turkish Society of Cardiology
New Directions in Postangioplasty Restenosis [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1999; 27(1): 44-55

New Directions in Postangioplasty Restenosis

Ubeydullah DELİGÖNÜL1

Although the probabil ity of restenosis following successful coronary balloon angioplasty reduced Tiirk Kardiyol Dem Arş 1999:27: 4-7 after stent implantation, it is stili an ongoing problem. The results of some drug trials (coumadine, heparin, low molecular weight heparin, hirudin, aspirin, dipyridamole, t ic lopidine, plate let glycoprotein Ilb/IIIa inhibitors, lovastatin, pravastat in, fluvastatin) are disappointing, and positive studies (probucol, trapidil) were not confirmed by randomized trials. The local application of heparin or urokinase are ine ffective in the decreasing the restenesis rate, but local delivery of enoxaparin prior to stent placement reduced restenosis in ;ı study. Gene therapies were not effective in preventing restenosis in humans. The results of the some methods (balloon angioplasty, rotablation, laser angioplasty) for the treatment of in-stent restenesis is unsatisfactory. In o ne study, stent implantation after coronary atherectomy significantly reduced the restenesis rate. Intracoronary radiation therapy may reduce restenosis. As a result, it may be concluded that none of the above mentioneel methods except stent implantation is seen to be e ffective in preve nting restenosis, but radiation therapy may be promising in the near future.


How to cite this article
Ubeydullah DELİGÖNÜL. New Directions in Postangioplasty Restenosis. Turk Kardiyol Dern Ars. 1999; 27(1): 44-55
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