Turk Kardiyol Dern Ars. Ahead of Print: TKDA-82668
The relationship between low thiol levels and major adverse cardiovascular events after primary percutaneous coronary intervention in patients with STEMI
, Mustafa Topuz1
, Hasan Koca1
, Hazar Harbalioğlu1
, Onur Kaypaklı1
, Mehmet Kaplan1
, Ömer Şen1
, Atilla Bulut1
, Hakim Çelik2
, Özcan Erel3
, Mustafa Gür11
Adana Numune Training And Research Hospital, Department Of Cardiology, Adana, Turkey2
Department Of Biochemistry, School Of Medicine, Harran University, Turkey3
Department Of Biochemistry, Yildirim Beyazit University, Ankara, Turkey
OBJECTIVE We aimed to investigate whether lower thiol levels are associated with the peri-procedural factors during primary percutaneous coronary intervention (pPCI) at the admission of ST-segment elevation myocardial infarction (STEMI) or not, and their prognostic value at six-month follow-up.
METHODS We enrolled 241 consecutive acute STEMI patients who underwent primary percutaneous coronary intervention (pPCI) and a control group of 67 individuals with normal coronary angiography.
RESULTS While age, contrast induced nephropathy, NT-proBNP, stent length and creatinine were related to native thiol, NT-proBNP, contrast induced nephropathy, and creatinine were related to total thiol. NT-proBNP was related to the disulphide levels. The left ventricular ejection fraction (LVEF), native thiol, total thiol, LDL and serum albumin were found to be independent predictors of major adverse cardiovascular events (MACEs) during 6 months of follow up.
CONCLUSION Initial lower native thiol, total thiol, LVEF, LDL and serum albumin may be used to identify patients with an increased long-term risk of unfavourable cardiac events in case of STEMI.
thiol, oxidative stress, acute myocardial infarction, coronary circulation, MACEs
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Corresponding Author: Oğuz Akkuş, Türkiye