Turk Kardiyol Dern Ars. 2018; 46(4): 248-259 | DOI: 10.5543/tkda.2018.82668
The relationship between low thiol levels and major adverse cardiovascular events after primary percutaneous coronary intervention in patients with STEMI
, Mustafa Topuz1
, Hasan Koca1
, Hazar Harbalioğlu1
, Onur Kaypaklı1
, Mehmet Kaplan1
, Ömer Şen1
, Atilla Bulut1
, Hakim Çelik2
, Özcan Erel3
, Mustafa Gür11
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey2
Department of Biochemistry, Harran University Faculty of Medicine, Şanlıurfa, Turkey3
Department of Biochemistry, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
OBJECTIVE The aim of this study was to investigate whether low thiol levels are associated with peri-procedural factors during primary percutaneous coronary intervention (pPCI) upon admission with ST-segment elevation myocardial infarction (STEMI), and the prognostic value at 6-month follow-up.
METHODS A total of 241 consecutive acute STEMI patients who underwent pPCI and a control group of 67 individuals with a normal coronary angiography were enrolled in the study.
RESULTS While age, contrast-induced nephropathy, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), stent length, and creatinine were related to native thiol, NT-proBNP, contrast-induced nephropathy, and creatinine were related to total thiol. NT-proBNP was also related to the disulphide level. The left ventricular ejection fraction (LVEF) and the levels of native thiol, total thiol, low-density lipoprotein, and serum albumin were found to be independent predictors of major adverse cardiovascular events (MACEs) during 6 months of follow-up.
CONCLUSION Initial lower native thiol, total thiol, LVEF, LDL, and serum albumin may be used to identify patients with an increased long-term risk of unfavorable cardiac events in case of STEMI.
Acute myocardial infarction, coronary circulation; major adverse cardiovascular events; oxidative stress; thiol.
How to cite this article
Oğuz Akkuş, Mustafa Topuz, Hasan Koca, Hazar Harbalioğlu, Onur Kaypaklı, Mehmet Kaplan, Ömer Şen, Atilla Bulut, Hakim Çelik, Özcan Erel, Mustafa Gür. The relationship between low thiol levels and major adverse cardiovascular events after primary percutaneous coronary intervention in patients with STEMI. Turk Kardiyol Dern Ars. 2018; 46(4): 248-259
Corresponding Author: Oğuz Akkuş, Türkiye