Archives of the Turkish Society of Cardiology
Epicardial fat thickness in patients with psoriasis vulgaris [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2014; 42(1): 47-54 | DOI: 10.5543/tkda.2014.78949

Epicardial fat thickness in patients with psoriasis vulgaris

Ahmet Bacaksız1, Abdurrahman Tasal1, Emrah Sevgili1, Ercan Erdoğan1, Nahide Onsun2, Osman Sönmez1, Buğçe Topukcu2, Emin Asoğlu1, Ömer Göktekin1
1Department of Cardiology, Bezmialem University Faculty of Medicine, Istanbul
2Department of Dermatology, Bezmialem University Faculty of Medicine, Istanbul


OBJECTIVES
Psoriasis vulgaris is one of the most common skin disorders. Patients with psoriasis carry an excessive risk of coronary artery disease. Visceral adipose tissue around the heart affects the heart and coronaries by secreting proatherogenic mediators. It can be evaluated easily by measurement of epicardial fat thickness (EFT). The aim of this study was to investigate EFT in patients with psoriasis vulgaris.

STUDY DESIGN
One hundred and fifteen adult patients (62 male; mean age 33.6±6.0 years) with psoriasis vulgaris (Group 1) and 60 age- and sex-matched healthy individuals (28 male; mean age, 32.5±8.3 years) (Group 2) were included in this study. EFT was obtained by transthoracic echocardiography. Disease-specific characteristics of the patients were recorded. Serum glucose, lipid profile and high-sensitive C-reactive protein (hs-CRP) levels were measured.

RESULTS
EFT and hs-CRP were significantly higher in Group 1 than in Group 2 (5.7±1.2 vs. 4.1±1.0 mm, p<0.001 and 0.52±0.45 mg/dl vs. 0.19±0.17 mg/dl, p<0.001, respectively). The psoriasis disease activity score and hs-CRP were found to be independent predictors of EFT in patients with psoriasis vulgaris (β=0.21, t=2.67, p=0.01 and β=0.62, t=7.72, p=0.001, respectively).

CONCLUSION
Our findings indicate that EFT was significantly higher in patients with psoriasis vulgaris compared with the controls. It was more prominent in patients with severe disease.

Keywords: Adipose tissue, atherosclerosis, C-reactive protein, psoriasis, heart rate.

How to cite this article
Ahmet Bacaksız, Abdurrahman Tasal, Emrah Sevgili, Ercan Erdoğan, Nahide Onsun, Osman Sönmez, Buğçe Topukcu, Emin Asoğlu, Ömer Göktekin. Epicardial fat thickness in patients with psoriasis vulgaris. Turk Kardiyol Dern Ars. 2014; 42(1): 47-54

Corresponding Author: Ahmet Bacaksız, Türkiye
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