Turk Kardiyol Dern Ars. Ahead of Print: TKDA-75133 | DOI: 10.5543/tkda.2018.75133
Influence of Smoking Habits on Acute Outcome of Revascularization of CTO
, Christian Blockhaus1
, Ruben Jansen1
, Johannes Stein1
, Julian Kürvers1
, Mathias Lehmann1
, Knut Kröger2
, Alexander Bufe11
Heartcentre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany2
Department of Angiology, Helios Clinic Krefeld, Krefeld, Germany
Percutaneous coronary intervention (PCI) of total chronic total occlusion (CTO) still remains a major challenge in interventional cardiology. The exact toxic components of cigarette smoke and the mechanisms involved in smoking-related cardiovascular dysfunction are largely unknown, but it increases inflammation, thrombosis, and oxidation of low-density lipoprotein cholesterol. There is only insignificant knowledge reported in the literature about the influence of smoking habits on acute outcome in CTO-PCI.
Between 2012-2017 we included 559 patients. They underwent PCI for at least one CTO. Antegrade and retrograde CTO techniques were applied. The Shapiro-Wilk test was used to test for normality of distribution. Continuous variables were tested for differences with the KruskalWallis-test or the MannWhitney-U test as appropriate. Categorical variables were tested with Fisher's exact test.
Non-smokers were older than smoking patients (65.3±10.3years vs. 58.3±9.2years;p=<0.001). The mean age oft he cohort was 62.1 years (±10.5). Smokers were more often male (85.7% vs. 79.7%;p=0.074), suffered from longer lesion length (36.1±17.5mm vs. 39.1±17.2mm;p=0.023) and needed therefore longer stents (64.2±26.5mm vs. 69.0±28.0mm;p=0.084). The success rates were comparable for smokers and non-smokers. In-hospital procedural complications were rare and showed no difference.
Our retrospective study suggests that there exists no significant association between smoking and non-smoking patients. Nevertheless they suffer from longer lesion length and needed longer stents.
chronic total occlusion, percutaneous coronary intervention, smoking habits,
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Corresponding Author: Jan-erik Guelker, Germany