Archives of the Turkish Society of Cardiology
Apolipoprotein A-II Levels and Risk of Coronary Disease, Metabolic Syndrome and Diabetes in a Group of Turkish Adults: A Pilot Study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2004; 32(4): 215-222

Apolipoprotein A-II Levels and Risk of Coronary Disease, Metabolic Syndrome and Diabetes in a Group of Turkish Adults: A Pilot Study

Gülay HERGENÇ1, Altan ONAT2, Vedat SANSOY3, Serdar TÜRKMEN4, İbrahim SARI5, Bülent UZUNLAR5, Hüseyin UYAREL5
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It is widely believed that apolipoprotein A-II (apo AII) lacks the antiatherogenic functions of apo AI. However, apo AII-containing HDL subfraction LpAI/AII, like LpAI, has been shown to be lower in coronary patients. Apo AII plays important roles in lipid metabolism. Associations of apo AII with inflammatory markers and coagulation system elements may prove further evidence on its role in atherogenesis though no consensus has yet been reached. Associations of apo AII with insulin resistance and diabetes are currently being investigated. Apolipoprotein AII, the second major apolipoprotein of HDL, was measured for the first time in 194 Turkish men and women with high coronary heart disease (CHD) risk in the cohort of the Marmara and Central Anatolian regions in the 2003 screening of the Turkish Adult Risk Factor Study. Associations of apo AII with CHD, metabolic syndrome (MS), diabetes and other risk factors were investigated in this pilot study. CHD, MS, diabetes and impaired fasting glucose were diagnosed in 49%, 29.9%, 19.6%, and 2.1%, respectively, in this study group. MS was observed twice as commonly in women (65.9%) as men. Highly significant correlations existed between apo AII and phospholipids, apo AI, HDL-C, total cholesterol (r=0.66 to 0.30, p=0.000), triglycerides, complement C3 (r=0.26 and 0.21, p<0.01), LDL-C, body mass index (r=0.17 and 0.15, p<0.05), (inversely) smoking (r = -0.26, p=0.002) and age (r= -0.15, p<0.05). A borderline association was noted between apo AII and MS. HDL-C and C3 emerged as the only independent determinants of apo AII levels among 12 parameters in a multivariate linear regression analysis. Sex- and age-adjusted apo AII did not prove to be significant for CHD, nor for MS and diabetes in logistic regression analyses. It will be desirable to further investigate these associations in a much larger group of healthy and affected individuals. (Türk Kardiyol Dern Arş 2004; 32: 215-222)

Keywords: Apolipoprotein A-II, coronary heart disease, epidemiology, metabolic syndrome

How to cite this article
Gülay HERGENÇ, Altan ONAT, Vedat SANSOY, Serdar TÜRKMEN, İbrahim SARI, Bülent UZUNLAR, Hüseyin UYAREL. Apolipoprotein A-II Levels and Risk of Coronary Disease, Metabolic Syndrome and Diabetes in a Group of Turkish Adults: A Pilot Study. Turk Kardiyol Dern Ars. 2004; 32(4): 215-222
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