Archives of the Turkish Society of Cardiology
Idiopathic dilated cardiomyopathy in children: Prognostic indicators [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2019; 47(3): 207-215 | DOI: 10.5543/tkda.2018.72809

Idiopathic dilated cardiomyopathy in children: Prognostic indicators

Mehmet Emre Arı1, Tamer Yoldaş2, Utku Arman Örün2, Selmin Karademir2
1Yıldırım Beyazıt University, Yenimahalle Training and Research Hospital, Pediatric Cardiology Clinics, Ankara, Turkey
2Dr. Sami Ulus Obstetrics and Gynecology, Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey


OBJECTIVE
Dilated cardiomyopathy (DCM) is a disorder featuring left ventricular dysfunction, heart failure, and a poor prognosis. The etiology is still unclear, despite diagnostic and therapeutic developments. This study was an evaluation of factors affecting the life span of a group of idiopathic DCM patients.

METHODS
A total of 79 patients from between October 2005 and October 2017 with a diagnosis of idiopathic DCM were evaluated retrospectively. Demographic characteristics, clinical information, left ventricular function, treatment, and follow-up of the patients were reviewed based on hospital records. Age, gender, parental consanguinity, cardiomegaly on telecardiography, reduced ejection fraction (EF) and shortening fraction (SF), degree of mitral regurgitation, and intracardiac thrombosis were determined to affect prognosis.

RESULTS
The patients were aged 20±60 months, and the male/female ratio was 1.02/1. The patients most frequently presented with heart failure signs and symptoms (n=59, 74.7%). The most common physical examination findings were a murmur (n=53, 67.1%) and tachycardia (n=48, 60.8%). Cardiomegaly was observed on telecardiography in 73.4% of the patients. The EF and SF values were 35.7±12.6% and 17.3±6.5%, respectively. In all, 42 (53.2%) patients had mitral regurgitation of grade 2 or higher. The duration of follow-up was between 1 and 156 months (20±34.9 months). Intracardiac thrombosis was detected in 4 (5.1%) patients. The mortality rate was 36.7%. When the prognostic factors were compared according to survival time, it was determined that survival was reduced in cases of parental consanguinity, low EF, and cardiomegaly.

CONCLUSION
The most important negative markers affecting the length of survival of DCM patients were parental consanguinity, cardiomegaly detected on telecardiography, and a reduced EF level.

Keywords: Children, dilated cardiomyopathy, prognosis.

How to cite this article
Mehmet Emre Arı, Tamer Yoldaş, Utku Arman Örün, Selmin Karademir. Idiopathic dilated cardiomyopathy in children: Prognostic indicators. Turk Kardiyol Dern Ars. 2019; 47(3): 207-215

Corresponding Author: Mehmet Emre Arı, Türkiye
© Copyright 2019 Archives of the Turkish Society of Cardiology
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