Archives of the Turkish Society of Cardiology
Relationship between endothelial dysfunction and cardiovascular risk factors and the extent and severity of coronary artery disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2014; 42(5): 435-443 | DOI: 10.5543/tkda.2014.72798

Relationship between endothelial dysfunction and cardiovascular risk factors and the extent and severity of coronary artery disease

Hilal Kurtoğlu Gümüşel1, Alp Burak Çatakoğlu1, Özlem Yıldırımtürk2, Selen Yurdakul2, Funda Helvacıoğlu1, Murat Ziyrek1, Ruken Hanavdeloğulları1, Vedat Aytekin2, Saide Aytekin2
1Department of Cardiology, Istanbul Bilim University Faculty of Medicine, Istanbul
2Department of Cardiology, Florence Nightingale Hospital, İstanbul


OBJECTIVE
Endothelial dysfunction (ED) is associated with coronary artery disease (CAD) and cardiovascular risk factors. The relationship between cardiovascular risk factors, ED and the presence, extent and severity of CAD, was evaluated in patients with and without angiographically defined CAD in our study.

METHOD
Eighty patients with CAD and 20 subjects with normal coronary arteries were included. Endothelial function was evaluated by endothelium-dependent flow-mediated dilatation (FMD) and nitroglycerine mediated dilatation (NMD) measurements, using brachial artery Doppler ultrasonography (USG). Cardiovascular risk factors were identified. The extent and severity of CAD was determined via vessel and modified Gensini scores.

RESULTS
FMD% and NMD% were significantly decreased in the CAD(+) group compared with the CAD(-) group (p=0.0001). In the CAD(+) group, the cut-off values of FMD% and NMD% in distinguishing between single-vessel and multi-vessel diseases were 8.5% (sensitivity: 95%, specificity: 62%) and 13.6% (sensitivity: 91%, specificity: 62%), respectively. Additionally, modified Gensini score was significantly correlated with both FMD and NMD (r=-0.825, r=-0.778, respectively, p=0.0001) in the CAD(+) group.

CONCLUSION
Endothelial dysfunction was more prevalent in the CAD(+) group and degree of ED correlated well with the extent and severity of CAD.

Keywords: Coronary artery disease, cardiovascular risk factors, endothelial dysfunction

How to cite this article
Hilal Kurtoğlu Gümüşel, Alp Burak Çatakoğlu, Özlem Yıldırımtürk, Selen Yurdakul, Funda Helvacıoğlu, Murat Ziyrek, Ruken Hanavdeloğulları, Vedat Aytekin, Saide Aytekin. Relationship between endothelial dysfunction and cardiovascular risk factors and the extent and severity of coronary artery disease. Turk Kardiyol Dern Ars. 2014; 42(5): 435-443

Corresponding Author: Saide Aytekin, Türkiye
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