Archives of the Turkish Society of Cardiology
Relationship between retinopathy and asymptomatic atherosclerosis determined by measurement of carotid intima-media thickness in patients with type 2 diabetes mellitus [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2016; 44(1): 24-29 | DOI: 10.5543/tkda.2015.69313

Relationship between retinopathy and asymptomatic atherosclerosis determined by measurement of carotid intima-media thickness in patients with type 2 diabetes mellitus

İbrahim Kocaoğlu1, Emine Kocaoğlu2, Uğur Arslan3, Mustafa Mücahit Balcı4, Murat Vural5, Mehmet Numan Alp5, Sinan Aydoğdu4
1Aydın State Hospital, Department Of Cardiology, Aydin - Turkey
2Aydın State Hospital, Department Of Ophthalmology, Aydin - Turkey
3Samsun Education And Research Hospital, Department Of Cardiology, Samsun - Turkey
4Turkiye Yuksek Ihtisas Education And Research Hospital, Department Of Cardiology, Ankara - Turkey
5Ankara Numune Education And Research Hospital, Department Of Radiology, Ankara - Turkey


OBJECTIVE
Presence of diabetic retinopathy (DR) may be used as an early marker of atherosclerosis in type 2 diabetes mellitus (DM) patients. This study aimed to investigate the relationship between the presence of DR and carotid intimamedia thickness (CIMT), which is an indicator of early atherosclerosis in patients with type 2 DM.

METHODS
Thirty DM patients with retinopathy (DR group), 28 DM patients without retinopathy (non-DR group), and 27 healthy controls (control group) were included in the study. CIMT was assessed using a high-resolution B-mode ultrasonography device.
RESULTS
Mean CIMT was found to be 0.9±0.17 mm in the DR group, 0.8±0.16 mm in the non-DR group, and 0.7±0.13 mm in the control group. CIMT was found to be statistically significantly higher in the DR group compared to the other 2 groups (p<0.001). When multivariate analysis was performed, presence of DR still remained as an independent risk factor for increased CIMT values.

CONCLUSION
Presence of DR in type 2 DM patients is an independent risk factor in terms of increased CIMT, which is considered to be a finding of subclinical atherosclerosis. Therefore, we believe that type 2 DM patients with retinopathy should be closely followed in terms of cardiovascular events.

Keywords: Atherosclerosis, carotid intima media thickness; diabetes mellitus; retinopathy.

İbrahim Kocaoğlu, Emine Kocaoğlu, Uğur Arslan, Mustafa Mücahit Balcı, Murat Vural, Mehmet Numan Alp, Sinan Aydoğdu. Relationship between retinopathy and asymptomatic atherosclerosis determined by measurement of carotid intima-media thickness in patients with type 2 diabetes mellitus. Turk Kardiyol Dern Ars. 2016; 44(1): 24-29

Corresponding Author: Uğur Arslan, Türkiye
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