Archives of the Turkish Society of Cardiology
Metabolic Syndrome, Major Culprit of Coronary Disease Among Turks: Its Prevalence and Impact on Coronary Risk [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2002; 30(1): 8-15

Metabolic Syndrome, Major Culprit of Coronary Disease Among Turks: Its Prevalence and Impact on Coronary Risk

Altan ONAT1, Vedat SANSOY1

The database of the survey 2000 of the Turkish Adult Risk Factor Study was analyzed cross-sectionally with the purpose of studying the prevalence, composition of the components of the metabolic syndrome (MS) and its relationship with the likelihood of coronary risk among Turkish adults. The population sample, measurements and definitions had previously been published. In this paper, MS was defined in conformity with that proposed in the new NCEP guidelines, namely in the presence of 3 out of 5 relevant components. MS was identified in a huge proportion of Turkish adults, namely in 28% of men and 45% of women aged (30 years. Among components of the MS, low HDL-cholesterol levels and hypertension in both genders as well as abdominal obesity (waist circumference >88 cm) in women each emerged in about 90% of instances, whereas hypertriglyceridemia (>150 mg/dl) existed in the majority and glucose intolerance in 1 out of each 5 individuals with MS. Fasting plasma insulin levels were elevated in MS by about 40-50% even in nondiabetic individuals. Hyperinsulinemia (?10 mIU/L) was associated in each 2 out of 5 subjects with MS. Coronary heart disease (CHD) had been diagnosed in 15.1% of men and 11.3% of women overall in MS. This meant that 53% of all CHD cases in Turkey was estimated to originate from MS. The CHD likelihood of MS was 2-fold that of the remaining adults; and even when controlled for age, an independent excess coronary risk of 60% was imposed by MS. Two criteria, namely total cholesterol/HDL-cholesterol ratio >5 and age ?50 in men, (55 in women were adequate to serve to identify subjects with MS at high risk (>20% likelihood of prevalent CHD). It was concluded that low HDL-cholesterol and hypertension, and in women abdominal obesity are the rule in MS among Turkish adults. MS, being associated with the majority of CHD cases in Turkey, poses the major attributable excess coronary risk. Findings were in agreement with the hypothesis that insulin resistance underlies MS even in nondiabetic persons The cholesterol ratio and age may justifiably be used to predict individuals with MS at high risk of CHD.


How to cite this article
Altan ONAT, Vedat SANSOY. Metabolic Syndrome, Major Culprit of Coronary Disease Among Turks: Its Prevalence and Impact on Coronary Risk. Turk Kardiyol Dern Ars. 2002; 30(1): 8-15
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