ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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Relation of elastic properties of pulmonary artery with left ventricular abnormalities and aortic stiffness in patients with moderate to severe obstructive sleep apnea: A cross-sectional echocardiographic study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2016; 44(4): 289-299 | DOI: 10.5543/tkda.2015.67862

Relation of elastic properties of pulmonary artery with left ventricular abnormalities and aortic stiffness in patients with moderate to severe obstructive sleep apnea: A cross-sectional echocardiographic study

İbrahim Halil Altıparmak1, Muslihittin Emre Erkuş1, Mustafa Polat2, Funda Yalçın3, Zafer Hasan Ali Sak3, Hatice Sezen4, Özgür Günebakmaz1, Yusuf Sezen1, Zekeriya Kaya1, Recep Demirbağ1
1Department Of Cardiology, Harran University, Sanliurfa, Turkey
2Sehit Kamil State Hospital, Department Of Cardiology, Gaziantep, Turkey
3Department Of Pulmonology, Harran University, Sanliurfa, Turkey
4Department Of Biochemistry, Harran University, Sanliurfa, Turkey


OBJECTIVE
In this study, the associations between pulmonary artery stiffness (PAS) and aortic stiffness, left ventricular diastolic parameters, and left ventricular mass (LVM) index in moderate to severe obstructive sleep apnea syndrome (OSAS) patients without coexisting disorders were investigated.

METHODS
A total of 66 non-diabetic, non-hypertensive, and non-smoking volunteers were enrolled. Participants were categorized by apnea-hypopnea index (AHI; event/hour). The control group was defined as no OSAS: AHI<5 (n=35), and OSAS group had moderate to severe OSAS: AHI>15 (n=31). Echocardiographic and biochemical tests, including measurement of C-reactive protein (CRP), were performed. PAS (kHz/s) was calculated by dividing the maximal frequency shift of the pulmonary flow by the acceleration time.

RESULTS
PAS (kHz/s), obtained by echocardiography, was statistically significantly higher in the OSAS group than the control group (28±5 vs 18±4, p<0.001), and was positively correlated with AHI, CRP, aortic stiffness index, E/E’, and LVM index (p=0.034, p=0.039, p<0.001, p=0.040, and p<0.001, respectively), and negatively correlated with aortic strain (AS), aortic distensibility (AD), E/A, E’/A’, and E’ (p<0.001). Regression analyses indicated that CRP and PAS are independent predictors of aortic stiffness (p<0.05). E/A and LVM index were independent predictors of PAS (p=0.002 and p=0.001, respectively).

CONCLUSION
Increased PAS is associated with aortic stiffness, left ventricular diastolic function, and increased LVM index. PAS may be a more effective indicator of aortic stiffness in OSAS patients than CRP.

Keywords: Aortic stiffness, C-reactive protein, left ventricle diastolic dysfunction, obstructive sleep apnea; pulmonary artery stiffness.

How to cite this article
İbrahim Halil Altıparmak, Muslihittin Emre Erkuş, Mustafa Polat, Funda Yalçın, Zafer Hasan Ali Sak, Hatice Sezen, Özgür Günebakmaz, Yusuf Sezen, Zekeriya Kaya, Recep Demirbağ. Relation of elastic properties of pulmonary artery with left ventricular abnormalities and aortic stiffness in patients with moderate to severe obstructive sleep apnea: A cross-sectional echocardiographic study. Turk Kardiyol Dern Ars. 2016; 44(4): 289-299

Corresponding Author: İbrahim Halil Altıparmak, Türkiye
Manuscript Language: English


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Journal Citation Indicator: 0.18
CiteScore: 1.1
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0.22
SCImago Journal Rank: 0.348

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