Archives of the Turkish Society of Cardiology
Long-term follow-up of antithrombotic management patterns in acute coronary syndrome patients [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-66724 | DOI: 10.5543/tkda.2017.66724

Long-term follow-up of antithrombotic management patterns in acute coronary syndrome patients

Fatih Sinan Ertaş1, Lale Tokgozoglu2, On Behalf Of The Epıcor Study Group1
1Department of Cardiology, Ankara University Faculty of Medicine, Ankara, Turkey
2Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey


OBJECTIVE
To evaluate post-discharge long-term follow-up of antithrombotic management patterns (AMPs), clinical outcomes and health status in a “real-life” setting for hospitalized acute coronary syndrome (ACS) patients.

METHODS
A total of 1034 patients (514 with STEMI and 520 with UA/NSTEMI) hospitalized for ACS within 24-h of symptom onset and survived to discharge were included. Data on follow-up AMPs, clinical outcomes and health status were collected during 24-month follow-up.

RESULTS
Overall all-cause mortality was 6.4% (6.7% in UA/NSTEMI and 6.0% in STEMI patients), cardiovascular (CV) events occurred in 9.4% (9.8% in UA/NSTEMI and 8.9% in STEMI patients) and bleeding events in 2.0% (2.3% in STEMI and 1.7% in UA/NSTEMI patients) of patients at 2 years post-discharge. EQ VAS scores were increased from 78.9 to 81.6 in STEMI, while from 76.0 to 76.2 in UA/NSTEMI patients. Discharge and 2- year post-discharge scores for EQ-5D index were 0.7 and 0.9, respectively in STEMI patients, while 0.8 for each period in UA/STEMI patients. Overall, 57.5% of the patients on dual antiplatelet therapy at discharge remained on these treatments for 2 years. Use of 1AP/0 anticoagulant (AC) and ≥2AP/0AC were associated with CV event risk of 10.5% and 8.9%, mortality risk of 10.5% and 5.8% and bleeding event risk of 0.9% and. 2.2%, respectively.

CONCLUSIONS
Our findings in a real-life population of ACS patients emphasize the importance of longer-term follow-up in ACS patients surviving hospitalization and support the likelihood of a more favorable long-term outcome via current treatment practices in ACS management.

Keywords: Acute coronary syndrome, ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, antithrombotic management, real-life setting, Turkey

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Corresponding Author: Fatih Sinan Ertaş, Türkiye
© copyright 2018 Archives of the Turkish Society of Cardiology
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