Archives of the Turkish Society of Cardiology
Heart failure prevalence and predictors in Turkey: HAPPY study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2012; 40(4): 298-308 | DOI: 10.5543/tkda.2012.65031

Heart failure prevalence and predictors in Turkey: HAPPY study

Muzaffer Degertekin1, Çetin Erol2, Oktay Ergene3, Lale Tokgözoğlu4, Mehmet Aksoy5, Mustafa Kemal Erol6, Mehmet Eren7, Mahmut Şahin8, Elif Eroğlu1, Bülent Mutlu9, Ömer Kozan10
1Yeditepe University Hospital Department of Cardiology, Istanbul, Turkey
2Ankara University Faculty of Medicine, Department of Cardiology, Ankara, Turkey
3Atatürk Heart And Research Hospital Department of Cardiology, Izmir, Turkey
4Hacettepe University Faculty of Medicine, Department of Cardiology, Ankara, Turkey
5Gaziantep University Faculty of Medicine, Department of Cardiology, Gaziantep, Turkey
6Mehmet Akif Ersoy Ersoy Heart And Research Hospital Department of Cardiology, İstanbul, Turkey
7Siyami Ersek Heart And Research Hospital Department of Cardiology, İstanbul, Turkey
819 Mayıs University Faculty of Medicine, Department of Cardiology, Samsun, Turkey
9Marmara University Faculty of Medicine, Department of Cardiology, Istanbul, Turkey
10Dokuz Eylül University Faculty of Medicine, Department of Cardiology, Istanbul, Turkey


OBJECTIVES
The aim of this study was to determine the prevalence of heart failure (HF) in adult residents of Turkey based on echocardiography and N-terminal B type natriuretic factor.

STUDY DESIGN
4650 randomly selected residents aged ≥35 years were enrolled. Height, weight, waist and hip circumference, and blood pressure measurements were taken, and a 12-lead ECG was performed. Advanced age, hypertension (HT), diabetes mellitus (DM), obesity, and chronic renal failure (CRF) were assessed. History of any heart disease, any abnormal ECG, or an NT-proBNP ≥120 pg/mL was accepted as echocardiography indication. Patients with systolic and/or diastolic dysfunction, or NT-proBNP ≥2000 pg/mL were classified as having HF if their functional capacity was NYHA ≥Class II, and were classified as having asymptomatic left ventricular dysfunction (ASVD) if their functional capacity was NYHA

RESULTS
The absolute and estimated prevalences were 2.9% and 6.9% for HF, and 4.8% and 7.9% for ASVD, respectively. Advanced age, male gender, history of heart disease, HT and CRF were independent predictors of HF. In patients with ejection fraction (EF) <50%, HF prevalence was higher in men, while HF prevalences were higher in women when EF≥50%. In global sum, HF and ALVD prevalence were similar in male and females.

CONCLUSION
The prevalences of HF and ASVD are higher in Turkey when compared with western countries, despite a younger Turkish population. The established predictors of HF are valid for Turkey as well. There is a significant ASVD population in Turkey with similar characteristics and risk factors to HF. Focusing on the early detection and treatment of ASVD may prevent the progression to HF, and therefore would decrease the prevalence of HF in Turkey.

Keywords: Biological markers, echocardiography, heart failure/epidemiology/etiology; natriuretic peptide, brain/blood; Turkey/epidemiology

How to cite this article
Muzaffer Degertekin, Çetin Erol, Oktay Ergene, Lale Tokgözoğlu, Mehmet Aksoy, Mustafa Kemal Erol, Mehmet Eren, Mahmut Şahin, Elif Eroğlu, Bülent Mutlu, Ömer Kozan. Heart failure prevalence and predictors in Turkey: HAPPY study. Turk Kardiyol Dern Ars. 2012; 40(4): 298-308

Corresponding Author: Muzaffer Degertekin, Türkiye
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