Turk Kardiyol Dern Ars. 2019; 47(5): 384-390 | DOI: 10.5543/tkda.2019.64569
Acute effects of synthetic cannabinoids on ventricular repolarization parameters
Süleyman Sezai Yıldız1
, Mehmet Necmeddin Sutaşır2
, Serhat Sığırcı1
, Hatice Topçu2
, Ahmet Gürdal1
, Kudret Keskin1
, Kadriye Orta Kılıçkesmez11
Department of Cardiology, University of Health Science, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey2
Department of Emergency Medicine, University of Health Science, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey
OBJECTIVE An association between ventricular repolarization parameters (VRPs) and ventricular arrhythmias has been demonstrated in previous studies. However, there are limited data related to a relationship between synthetic cannabinoids (SCs) and VRPs. The aim of this study was to analyze the acute effects of SCs on VRPs using electrocardiogram (ECG) measurements of the T-peak to T-end interval (Tp-e), Tp-e/QT ratio, and Tp-e/corrected QT (QTc) ratio.
METHODS The present study included 58 patients who were admitted to the emergency department who used SCs (SC +) between 2014 and 2016, and 50 healthy control subjects (SC -). The QT and QTc intervals, Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were measured from a 12-lead ECG. These parameters were compared between groups and correlation analysis was performed.
RESULTS The Tp-e and QTc intervals were significantly higher in SC + patients when compared with the SC- group (92.2±10.0, 77.4 ±9.3, p<0.001; 434.5±30.8, 410.9±27.3, p<0.001, respectively). Tp-e/QT and Tp-e/QTc ratios were greater in SC + patients in comparison with SC participants (0.26±0.02, 0.22±0.02, p<0.001; 0.21±0.02, 0.18±0.02, p<0.001, respectively). Significant correlations were found between the use of SCs and the Tp-e interval (r=0.610; p<0.001), Tp-e/QT (r=0.655; p<0.001) and Tp-e/ QTc ratios (r=0.437; p<0.001).
CONCLUSION The Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were greater in subjects who used SCs. Therefore, SC users might have an increased risk of ventricular arrhythmia.
Acute effects, synthetic cannabinoids; ventricular repolarization parameters.
How to cite this article
Süleyman Sezai Yıldız, Mehmet Necmeddin Sutaşır, Serhat Sığırcı, Hatice Topçu, Ahmet Gürdal, Kudret Keskin, Kadriye Orta Kılıçkesmez. Acute effects of synthetic cannabinoids on ventricular repolarization parameters. Turk Kardiyol Dern Ars. 2019; 47(5): 384-390
Corresponding Author: Süleyman Sezai Yıldız, Türkiye