Archives of the Turkish Society of Cardiology
Homocysteine and Cardiovascular Disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2001; 29(3): 181-190

Homocysteine and Cardiovascular Disease

Murat SUCU1, A. Aziz KARADEDE1, Nizamettin TOPRAK1
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Homocysteine is a sulphur-containing ażnino acid formed during the żnetabolisżn of żnethionine . It is żnetabolised by reżnethy lation or transsulphuration. Fasting normal ranges are 5- ż 5 żżżnoi/L in the general population. Plasma hożnoc yste ine ż eve l s are strongly influenced by diet, as well as genetic factors. It is suggested that atherogenic propensity associated with h yperhożnocysteineżn i a results from endothelial dysfunction and injury. Although there is considerable epideżn i ologica l evidence for a relation between plasżna hożnocyste ine and cardiovascular disease, not all prospective studies have supported such a relationship. Moreover, despite the potential for reducing hożnocysteine levels with increased intake of folic acid, it is not known whether reduction of plasżna hożnocyste ine by diet and/or vitamin therapy wi ll reduce cardiovascular disease risk. Hożnocysteine leveżs of mo re than ż 5 żżm oi/L żnay be żnanaged with 400 żżg folate with or without other B vitamins.

Keywords: Homocysteine, cardiovascular disease

How to cite this article
Murat SUCU, A. Aziz KARADEDE, Nizamettin TOPRAK. Homocysteine and Cardiovascular Disease. Turk Kardiyol Dern Ars. 2001; 29(3): 181-190
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