Archives of the Turkish Society of Cardiology
Iron Deficiency and Hematinic Deficiencies in Atrial Fibrillation: A New Insight into Comorbidities [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-51001 | DOI: 10.5543/tkda.2018.51001

Iron Deficiency and Hematinic Deficiencies in Atrial Fibrillation: A New Insight into Comorbidities

Muhammed Keskin1, Dilek Ural2, Servet Altay3, Onur Argan2, Edibe Betül Börklü4, Ömer Kozan1
1Sultan Abdulhamid Han Training and Research Hospital, Department of Cardiology, Istanbul, Turkey
2Kocaeli University Medical Faculty, Department of Cardiology, Istanbul, Turkey
3Trakya University Medical Faculty, Department of Cardiology, Edirne, Turkey
4Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology Istanbul, Turkey

Background
Iron deficiency (ID) is the most common nutritional deficiency. ID has been widely considered as an important co-morbidity in patients with heart failure (HF). However, atrial fibrillation (AF) is the most common arrhythmia and HF and AF have a common pathophysiology; ID in AF has not been evaluated.
Methods
In this retrospective observational study, we evaluated 101 patients with non-valvular atrial fibrillation. Iron deficiency was defined as serum ferritin< 100 µg/L, or serum ferritin ≥100 µg/L and ≤300 µg/L with transferrin saturation <20%.
Results
A total of 48 (47.6%) patients had ID. Univariate logistic regression models demonstrated that permanent vs. paroxysmal AF [OR 2.17; confidence interval (CI) 0.82 – 5.69; P= 0.011] high sensitive C-reactive protein (OR 1.47; CI 0.93 – 2.36; P= 0.019), N-terminal pro B-type natriuretic peptide (OR 1.24; CI 0.96 – 1.71; P= 0.034) and white blood cell count count (OR 1.21; 0.95 – 1.58; P= 0.041) were associated with ID (Table 2). Based on a multivariable logistic regression model permanent vs. paroxysmal AF remained as an independent clinical associate with ID (OR 4.30; 0.83 – 12.07; P= 0.039).
Conclusion
As in HF, ID is common in AF. According to our results, permanency and underlying inflammatory mechanisms have been found as responsible mechanisms. The current study suggests evaluating the iron status in patients with AF.

Keywords: Atrial fibrillation, iron deficiency, inflammation

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Corresponding Author: Muhammed Keskin, Türkiye
© Copyright 2018 Archives of the Turkish Society of Cardiology
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