Turk Kardiyol Dern Ars. Ahead of Print: TKDA-49393 | DOI: 10.5543/tkda.2018.49393
Impact of 25(OH)D3 on Spontaneous Reperfusion and SYNTAX Score in Patients with ST Elevation Myocardial Infarction
Oğuz Akkuş, Mustafa Topuz
, Fahrettin Öz, Hazar Harbalıoğlu, Hasan Koca, Mehmet Kaplan, Ömer Şen, Atilla Bulut, Mustafa Gür
Adana Numune Education And Research Hospital
OBJECTIVE We aim to evaluate the potential relationship between 25(OH)D3, Synergy Between PCI with Taxus and Cardiac Surgery (SYNTAX) score and spontaneous reperfusion (SR) in patients with ST elevation myocardial infarction (STEMI).
METHODS 148 consecutive patients with acute STEMI, underwent primary percutaneous coronary intervention (pPCI), were retrospectively enrolled into the study.
RESULTS 36 patients with TIMI 3 flow (spontaneous reperfusion) before coronary intervention served as group 1, and 112 patients with TIMI 0-2 flow served as group 2. SYNTAX score and in-hospital MACE (major adverse cardiovascular events) rates were significantly higher in group 2 (p<0.001, p=0.012; respectively). Mean 25(OH)D3 level was significantly higher in group 1 (p=0.003). Since age, Killip class, left ventricular ejection fraction (LVEF), N-terminal pro-B-type natriuretic peptide were both correlated with SYNTAX score and 25(OH)D3, troponin-I, CRP and creatinine were lonely, however weakly, correlated with SYNTAX score. According to multilogistic regression analysis SYNTAX score (p<0.001), Rentrop collateral (p=0.049), and troponin-I (p=0.004) were significantly, 25(OH)D3 (p=0.079) and high density lipoprotein (p=0.055) were borderline effective in predicting SR.
CONCLUSION Lower levels of 25(OH)D3 may be associated with the absence of SR, increased disease severity, and in hospital MACE rates in patients with STEMI.
myocardial infarction, coronary artery disease severity, coronary flow, 25(OH)D3, spontaneous reperfusion
How to cite this article
Corresponding Author: Mustafa Topuz, Türkiye