Archives of the Turkish Society of Cardiology
Impact of 25(OH)D3 on spontaneous reperfusion and SYNTAX score in patients with ST-elevation myocardial infarction [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2018; 46(4): 268-275 | DOI: 10.5543/tkda.2018.49393

Impact of 25(OH)D3 on spontaneous reperfusion and SYNTAX score in patients with ST-elevation myocardial infarction

Oğuz Akkuş, Mustafa Topuz, Fahrettin Öz, Hazar Harbalıoğlu, Hasan Koca, Mehmet Kaplan, Ömer Şen, Atilla Bulut, Mustafa Gür
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey


OBJECTIVE
The aim of this study was to evaluate the potential relationship between 25-hydroxyvitamin D3 (25[OH]D3), the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score, and spontaneous reperfusion (SR) in patients with ST-elevation myocardial infarction (STEMI).

METHODS
A total of 148 consecutive patients with acute STEMI who underwent primary percutaneous coronary intervention were retrospectively enrolled in the study.

RESULTS
In all, 36 patients with a TIMI 3 flow score (spontaneous reperfusion [SR]) before coronary intervention constituted Group 1, and 112 patients with a TIMI flow score of 0-2 served as Group 2. The SYNTAX score and the in-hospital major adverse cardiovascular event (MACE) rate were significantly higher in Group 2 (p<0.001, p=0.012, respectively). The mean 25(OH)D3 level was significantly higher in Group 1 (p=0.003). Age, Killip class, left ventricular ejection fraction, and N-terminal pro-B-type natriuretic peptide were correlated with the SYNTAX score, and 25(OH)D3, troponin-I, C-reactive protein, and creatinine were weakly correlated with the SYNTAX score. Multilogistic regression analysis indicated that the SYNTAX score (p<0.001), Rentrop collateral (p=0.049), and troponin-I (p=0.004) were significantly effective at predicting SR, and 25(OH)D3 (p=0.079) and high-density lipoprotein (p=0.055) were borderline effective.

CONCLUSION
A lower level of 25(OH)D3 may be associated with the absence of SR, increased disease severity, and in-hospital MACE rates in patients with STEMI.

Keywords: 25-hydroxyvitamin D3, coronary artery disease severity; coronary flow; myocardial infarction; spontaneous reperfusion.

How to cite this article
Oğuz Akkuş, Mustafa Topuz, Fahrettin Öz, Hazar Harbalıoğlu, Hasan Koca, Mehmet Kaplan, Ömer Şen, Atilla Bulut, Mustafa Gür. Impact of 25(OH)D3 on spontaneous reperfusion and SYNTAX score in patients with ST-elevation myocardial infarction. Turk Kardiyol Dern Ars. 2018; 46(4): 268-275

Corresponding Author: Mustafa Topuz, Türkiye
© Copyright 2018 Archives of the Turkish Society of Cardiology
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