ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(7): 599-606 | DOI: 10.5543/tkda.2015.44457

Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels

Süleyman Yüce1, Erkan Cüre1, Yüksel Çiçek2, Medine Cumhur Cüre3, Arif Yılmaz1, Bayram Kızılkaya1
1University of Recep Tayyip Erdoğan School of Medicine, Department of Internal Medicine, Rize, Turkey
2University of Recep Tayyip Erdoğan School of Medicine, Department of Cardiology,rize, Turkey
3University of Recep Tayyip Erdoğan School of Medicine, Department of Biochemistry,rize, Turkey


OBJECTIVE
Gilbert’s syndrome (GS) is an autosomal recessive disease that is characterized by an increase in indirect bilirubin (IB). The incidence of atherosclerotic heart disease is decreased in GS. This study aimed to investigate the relation between pulse wave velocity (PWV) and the presence of GS.

METHODS
The study included 58 GS patients (32 females, age; 27.12±7.27 years, 26 males, age; 26.63±5.84 years) admitted to the internal medicine clinic of the hospital. The control group included 58 healthy individuals (35 females [27.33±8.06 years old, p=0.716] and 23 males [27.38±6.91 years old, p=0.923]). PWV of both groups was measured from the right carotid and femoral arteries.

RESULTS
Mean age of the GS group was 26.03±8.22 years, while that of the healthy group was 26.60±5.84 years. The GS group’s diastolic blood pressure and PWV were significantly lower than those of the control group: 67.76±8.59 mmHg vs 71.72±7.28 mmHg; p=0.008, and 5.63±1.12 m/s vs 6.18±1.22 m/s; p=0.014 respectively. The GS group’s high density lipoprotein (HDL) level was significantly higher than that of the control group: 1.4±0.3 mmol/L vs 1.2±0.3 mmol/L, p=0.029.

CONCLUSION
This study found PWV among GS patients to be lower than that among non-smoking and aged-matched healthy controls.

Keywords: Atherosclerotic heart disease, bilirubin, Gilbert’s syndrome, pulse wave velocity

How to cite this article
Süleyman Yüce, Erkan Cüre, Yüksel Çiçek, Medine Cumhur Cüre, Arif Yılmaz, Bayram Kızılkaya. Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. Turk Kardiyol Dern Ars. 2015; 43(7): 599-606

Corresponding Author: Erkan Cüre, Türkiye
Manuscript Language: English


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Journal Citation Indicator: 0.18
CiteScore: 1.1
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0.22
SCImago Journal Rank: 0.348

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