ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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Association between mean platelet volume and severity of disease in patients with obstructive sleep apnea syndrome without risk factors for cardiovascular disease [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2013; 41(1): 14-20 | DOI: 10.5543/tkda.2013.42948

Association between mean platelet volume and severity of disease in patients with obstructive sleep apnea syndrome without risk factors for cardiovascular disease

Mustafa Serkan Karakaş1, Refik Emre Altekin2, Ahmet Oğuz Baktır3, Murathan Küçük2, Aykut Çilli4, Selim Yalçınkaya2
1Department of Cardiology, Nigde State Hospital, Niğde, Turkey
2Department of Cardiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
3Department of Cardiology, Kayseri Training and Research Hospital, Kayseri, Turkey
4Department of Chest Diseases, Akdeniz University Faculty of Medicine, Antalya, Turkey


OBJECTIVES
Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular morbidity and mortality. Platelet activation and aggregation are central processes in the pathophysiology of atherothrombosis. Mean platelet volume (MPV), a determinant of platelet activation, is a newly-emerging risk factor for atherothrombosis. Therefore, we have investigated the possible association between OSAS and MPV.
STUDY DESIGN
We selected 30 mild, 32 moderate, and 31 severe OSAS patients and 31 healthy control subjects matched for age, sex, and body mass index. MPV was measured using an automated blood cell counter.
RESULTS
The MPV levels were significantly higher in the severe OSA group than in the control group (8.6±1.1 vs. 7.8±0.7 fl, p=0.03). There were no significant differences in respect to MPV between controls and patients with mild and moderate OSA (7.8±0.7 vs. 8.3±1.2 fl, p=0.2; 7.8±0.7 vs. 8.4±1.3 fl, p=0.08) and between patients with mild, moderate, and severe OSA (8.3±1.2 vs. 8.4±1.3 vs. 8.6±1.1 fl, p=0.9). Significant correlations were seen between MPV and apneahypopnea index (r=0.347, p≤0.001), minimal oxygen saturation (r=-0.224, p=0.03), and the percentage of recording time spent at a oxygen saturation less than 90% (r=0.240, p=0.02).
CONCLUSION
Our results suggest that OSAS patients tend to have relatively increased platelet activation andatherothrombotic risk.

Keywords: Cardiovascular diseases, platelet activation; platelet count; sleep apnea, obstructive/complications/diagnosis.

How to cite this article
Mustafa Serkan Karakaş, Refik Emre Altekin, Ahmet Oğuz Baktır, Murathan Küçük, Aykut Çilli, Selim Yalçınkaya. Association between mean platelet volume and severity of disease in patients with obstructive sleep apnea syndrome without risk factors for cardiovascular disease. Turk Kardiyol Dern Ars. 2013; 41(1): 14-20

Corresponding Author: Mustafa Serkan Karakaş, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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