Archives of the Turkish Society of Cardiology
The importance of fragmented QRS complexes in prediction of myocardial infarction and reperfusion parameters in patients undergoing primary percutaneous coronary intervention [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2012; 40(3): 213-222 | DOI: 10.5543/tkda.2012.36937

The importance of fragmented QRS complexes in prediction of myocardial infarction and reperfusion parameters in patients undergoing primary percutaneous coronary intervention

Sinan Altan Kocaman1, Mustafa Cetin1, Tuncay Kiris2, Turan Erdogan3, Aytun Canga1, Emre Durakoglugil3, Omer Satiroglu3, Asife Sahinarslan4, Yuksel Cicek3, Ismail Sahin1, Mehmet Bostan3
1Rize Education And Research Hospital, Department of Cardiology, Rize, Turkey
2Ordu State Hospital, Department of Cardiology, Ordu, Turkey
3Rize University, Faculty of Medicine, Department of Cardiology, Rize, Turkey
4Gazi University, Faculty of Medicine, Department of Cardiology, Ankara, Turkey


OBJECTIVES
The QRS complex fragmentations (fQRS) frequently seen on admission electrocardiograms (ECGs) with narrow or wide QRS complex are associated with increased morbidity and mortality. The causative relationship between fQRS and cardiac fibrosis is known, but the relation of fragmented QRS before and after primary percutaneous coronary intervention (p-PCI) with myocardial infarction and reperfusion parameters has not been studied until now.

STUDY DESIGN
The study included 184 consecutive patients with ST elevation myocardial infarction (STEMI) who underwent p-PCI. Presence or absence of fQRS on pre- and post-PCI ECGs and its change following PCI were investigated. In addition, independent predictors of fQRS were also investigated. Patients with significant organic valve disease and patients having any QRS morphology with QRS duration ≥120 ms as well as patients with permanent pacemakers were excluded from the study.

RESULTS
Patients with fQRS on admission ECG had higher leukocyte counts (p=0.001), higher CK-MB (p=0.001) and troponin levels (p=0.005), increased pain to balloon time (p=0.004), higher Killip score (p<0.001), prolonged QRS time (p<0.001), higher Gensini score (p<0.001) and more frequent Q waves on ECG (p<0.001) in comparison to patients with non-fragmented QRS. In addition, these patients usually had an infarction of anterior territory related to a lesion in proximal LAD and wider jeopardized myocardium (p<0.001). fQRS was significantly related to infarction and myocardial reperfusion parameters before and after p-PCI. In the setting of STEMI, absence of fQRS on admission ECG predicted increased ST resolution, higher reduction in QRS duration, and better myocardial reperfusion.

CONCLUSION
FQRS may be useful in identifying patients at higher cardiac risk with larger areas of ischemic jeopardized or necrotic myocardium.

Keywords: Coronary artery disease, electrocardiography, heart failure/diagnosis, myocardial infarction; myocardial reperfusion; primary coronary intervention; prognosis; risk factors; ST elevation myocardial infarction

How to cite this article
Sinan Altan Kocaman, Mustafa Cetin, Tuncay Kiris, Turan Erdogan, Aytun Canga, Emre Durakoglugil, Omer Satiroglu, Asife Sahinarslan, Yuksel Cicek, Ismail Sahin, Mehmet Bostan. The importance of fragmented QRS complexes in prediction of myocardial infarction and reperfusion parameters in patients undergoing primary percutaneous coronary intervention. Turk Kardiyol Dern Ars. 2012; 40(3): 213-222

Corresponding Author: Sinan Altan Kocaman, Türkiye
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