Turk Kardiyol Dern Ars. Ahead of Print: TKDA-35005 | DOI: 10.5543/tkda.2018.35005
Macrophage migration inhibitory factor gene -173 G>C polymorphism and its relationship with coronary artery disease and diabetes
, Aycan Fahri Erkan2
, Berkay Ekici2
, Maide Kaşit1
, Nihan Erginel Ünaltuna1
, Eren Vurgun11
Department Of Genetics, Aziz Sancar Institute For Experimental Medicine, Istanbul University2
Department Of Cardiology, Medical Faculty, Ufuk University
Recent studies indicate that macrophage migration inhibitory factor (MIF) is a potent proinflammatory cytokine which mediates the inflammatory process during atherosclerosis. The purpose of the study was to investigate the association between MIF gene polymorphism and type2 diabetes mellitus (T2DM) with coronary artery disease (CAD) and without CAD in Turks.
Unselected 259 Turkish significant CAD (coronary lesion with 50-100% stenosis) and control (coronary lesion with <30% stenosis) were genotyped for MIF rs755622 polymorphisms using hybridization probes in Real-Time PCR LC480 device. Blood samples were drawn before coronary angiography. Gensini and SYNTAX scores were assessed in order to determine angiographic extent and severity of CAD.
When the case control groups were stratified according to T2DM, polymorphism of MIF was not associated with T2DM in CAD (p>0.05). In contrast, in the same subgroups, compared to noncarriers, carriers of the MIF common allel show a protection against developing the T2DM in control group (p<0.05). In addition, MIF C allele carriage was associated with higher HbA1c in T2DM group (p=0.038).
MIF rs755622 polymorphisms associated with HbA1c. This results suggest that the MIF gene variant may contribute to the CAD risk through diabetes in the Turkish population.
MIF gene, polymorphism, CAD, T2DM.
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Corresponding Author: Neslihan Çoban, Türkiye