Archives of the Turkish Society of Cardiology
Comparison of the effects of high-dose atorvastatin and high-dose rosuvastatin on oxidative stress in patients with acute myocardial infarction: A pilot study [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2017; 45(3): 235-243 | DOI: 10.5543/tkda.2017.22792

Comparison of the effects of high-dose atorvastatin and high-dose rosuvastatin on oxidative stress in patients with acute myocardial infarction: A pilot study

Celal Kilit1, Fatma Emel Koçak2, Türkan Paşalı Kilit3
1Department of Cardiology, Dumlupınar University School of Medicine, Kütahya, Turkey
2Department of Medical Biochemistry, Dumlupınar University School of Medicine, Kütahya, Turkey
3Department of Internal Medicine, Dumlupınar University School of Medicine, Kütahya, Turkey


OBJECTIVE
Oxidative stress is increased in patients with acute myocardial infarction (AMI). Statins reduce oxidative stress independent of their effect in reducing low-density lipoprotein cholesterol (LDL-C). The aim of the present study was to compare the effects of atorvastatin and rosuvastatin on oxidative status by investigating serum paraoxonase, serum arylesterase, total oxidant status, total antioxidant status (TAS) and oxidative stress index (OSI) in patients with AMI.

METHODS
Seventy patients with AMI were randomized into 2 groups; total of 55 patients (19 females, 36 males) aged 32 to 86 years completed the study and were included in the analysis. Patients were treated with 80 mg atorvastatin or 40 mg rosuvastatin for 4 weeks. Lipid parameters and parameters of oxidative status were measured at admission and after 4-week statin treatment.

RESULTS
After 4-week treatment, atorvastatin and rosuvastatin were associated with significant reduction in TAS, OSI, total cholesterol, and LDL-C levels. Serum paraoxonase level was significantly increased in both groups, while high-density lipoprotein cholesterol (HDL-C) level was significantly reduced in atorvastatin group. No statistically significant differences were found between atorvastatin and rosuvastatin in terms of actual difference in oxidative stress parameters.

CONCLUSION
Atorvastatin and rosuvastatin have similar effects on oxidative status in patients with AMI. Rosuvastatin affected HDL-C level more favorably than atorvastatin.

Keywords: Acute myocardial infarction, arylesterase, oxidative stress, paraoxonase, statin.

How to cite this article
Celal Kilit, Fatma Emel Koçak, Türkan Paşalı Kilit. Comparison of the effects of high-dose atorvastatin and high-dose rosuvastatin on oxidative stress in patients with acute myocardial infarction: A pilot study. Turk Kardiyol Dern Ars. 2017; 45(3): 235-243

Corresponding Author: Celal Kilit, Türkiye
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