ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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Relationship between serum osteopontin level and atrial fibrillation recurrence in patients undergoing cryoballoon catheter ablation [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2017; 45(1): 26-32 | DOI: 10.5543/tkda.2016.21855

Relationship between serum osteopontin level and atrial fibrillation recurrence in patients undergoing cryoballoon catheter ablation

Hacı Murat Güneş1, Gamze Babur Güler1, Ekrem Güler1, Gültekin Günhan Demir1, Filiz Kızılırmak Yılmaz1, Mehmet Onur Omaygenç1, Ayşe İstanbullu Tosun2, Taylan Akgün3, Bilal Boztosun1, Fethi Kılıçarslan1
1İSTANBUL MEDİPOL UNİVERSİTY MEDİCİNE FACULTY CARDİOLOGY DEPARTMENT
2İstanbul Medi̇pol Uni̇versi̇ty Medi̇ci̇ne Faculty Bi̇ochemi̇stry Department
3KARTAL KOŞUYOLU HEART HOSPİTAL CARDİOLOGY CLİNİC


OBJECTIVE
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with increased morbidity and mortality. Atrial fibrosis augments recurrence rate following AF catheter ablation. Osteopontin is a multifunctional molecule involved in several pathophysiological pathways, including fibrosis. Presently described is investigation of relationship between serum osteopontin level and AF recurrence after AF cryoablation.

METHODS
The study was designed to be prospective and observational; 60 patients with paroxysmal (n=47) and persistent (n=13) AF were included. Osteopontin level was measured both before and 6 months after AF ablation with cryoballoon.

RESULTS
Preprocedure and postprocedure osteopontin level did not differ between the 2 groups of AF patients (p=0.286, p=0.493, respectively). Postprocedure osteopontin level was significantly higher compared with preprocedure value (32.18 ng/mL vs 15.58 ng/mL; p=<0.001). Left atrial diameter, AF type, and preprocedure osteopontin level were related to AF recurrence (p≤0.05). An age-adjusted multivariate logistic regression analysis was conducted to determine independent predictors of AF recurrence. Among these, AF type (β=2.211; p=0.004; odds ratio [OR]: 9.124; 95% confidence interval [CI]: 2.026–41.094) was found to be the most important factor related to AF recurrence. Preprocedure osteopontin level also predicted AF recurrence independently (β=0.059; p=0.048; OR: 1.061; 95% CI 1.001–1.125).

CONCLUSION
Study results revealed persistency of AF and high preprocedure osteopontin level independently predicted AF recurrence in patients undergoing cryoballoon AF ablation. Association of a biochemical marker with AF recurrence might be beneficial to selection of appropriate patients for cryoballoon procedure and assessment of long-term procedural success.

Keywords: Atrial fibrillation catheter ablation, atrial fibrillation recurrence, cryoballoon, osteopontin.

How to cite this article
Hacı Murat Güneş, Gamze Babur Güler, Ekrem Güler, Gültekin Günhan Demir, Filiz Kızılırmak Yılmaz, Mehmet Onur Omaygenç, Ayşe İstanbullu Tosun, Taylan Akgün, Bilal Boztosun, Fethi Kılıçarslan. Relationship between serum osteopontin level and atrial fibrillation recurrence in patients undergoing cryoballoon catheter ablation. Turk Kardiyol Dern Ars. 2017; 45(1): 26-32

Corresponding Author: Hacı Murat Güneş, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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