Turk Kardiyol Dern Ars. Ahead of Print: TKDA-17666 | DOI: 10.5543/tkda.2017.17666
The association of serum hepcidin-25 level with subclinical atherosclerosis in peritoneal dialysis patients
, Barış Eser2
, Özlem Yayar3
, Mehmet Deniz Aylı41
Yunus Emre State Hospital, Department of Nephrolgy, Eskisehir, Turkey2
Hitit University, Erol Olcok Training and Research Hospital, Department of Nephrology, Corum, Turkey3
Canakkale State Hospital, Department of Nephrology, Canakkale, Turkey4
Diskapi Yildirim Beyazid Training and Research Hospital, Department of Nephrology, Ankara, Turkey
OBJECTIVE Recently, the role of hepcidin as a cardiovascular marker gained interest in chronic kidney disease (CKD) population. The aim of this study is to investigate the relation of serum hepcidin-25 (SH-25), inflammation, iron parameters, and carotid intima-media thickness (CIMT) in peritoneal dialysis (PD) patients.
METHODS Fifty-eight patients (30 male 51.3%, mean age 46.8±13.6 years, mean dialysis vintage 69.2±39.1 months) were included in this cross-sectional study. Clinical and routine laboratory data were recorded and CIMT and SH-25 values were determined. The study population was grouped into two according to a median value of SH-25 of 60 ng/mL. In addition, correlation analysis and logistic regression analysis were applied to determine the relationship between SH-25 level and other parameters.
RESULTS Age (p=0.003), systolic blood pressure (p=0.039), body mass index (p=0.031), glucose (p=0.028), C-reactive protein (CRP) (p<0.001) and CIMT (p=0.011) were found to be statistically significantly higher in high SH-25 group. In correlation analysis, SH-25 was positively correlated with age (p<0.001), dialysis vintage (p=0.041), glucose (p=0.015), ferritin (p=0.005), CRP (p<0.001) and CIMT (p=0.035). In multivariate linear regression analysis, age (p<0.001) and CRP (p=0.005) were found to be related to CIMT.
CONCLUSIONS SH-25 is strongly associated with both age and CRP in patients undergoing PD treatment. Results implicate that hepcidin may be involved in the pathophysiology of atherosclerosis. In this patient population, prospective studies should be carried out to determine whether hepcidin has an effect on atherosclerosis.
Carotid intima-media thickness, hepcidin, inflammation, peritoneal dialysis.
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Corresponding Author: Barış Eser, Türkiye