Archives of the Turkish Society of Cardiology
The relationship between echocardiographic epicardial adipose tissue, P-wave dispersion, and corrected QT interval [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2018; 46(6): 471-478 | DOI: 10.5543/tkda.2018.01578

The relationship between echocardiographic epicardial adipose tissue, P-wave dispersion, and corrected QT interval

Alaa Quisi1, Serhat Emre Şentürk2, Hazar Harbalıoğlu2, Ahmet Oytun Baykan2
1Department of Cardiology, Medline Adana Hospital, Adana, Turkey
2Department of Cardiology, University of Health Sciences, Adana Numune Training and Research Hospital, Adana, Turkey


OBJECTIVE
Epicardial adipose tissue (EAT) secretes various pro-inflammatory and atherogenic substances that have several effects on the heart. The goal of this study was to evaluate the association between EAT thickness and both P-wave dispersion (Pd) and corrected QT interval (QTc), as simple, non-invasive indicators of arrhythmia on a surface electrocardiogram.

METHODS
This retrospective observational study included 216 patients who had normal coronary arteries observed on coronary angiography. Each patient underwent 12-derivation electrocardiography to measure Pd and QTc, and transthoracic echocardiography to measure EAT thickness. The patients were divided into 2 groups according to the median EAT value (EAT low group: <5.35 mm; EAT high group: ≥5.35 mm).

RESULTS
P-wave dispersion (p=0.001) was significantly greater in the EAT high group compared with the EAT low group. However, the QTc (p=0.004) was significantly greater in the latter group. The median left ventricular end-diastolic diameter (p=0.033), mean left ventricular end-systolic diameter (p=0.039), and mean left atrial diameter (p=0.012) were significantly greater in the EAT high group. Multiple logistic regression analysis using the backward elimination method revealed that the leukocyte count (Odds ratio [OR]: 1.000; 95% confidence interval [CI]: 1.000–1.000; p=0.001), Pd (OR: 1.1026; 95% CI: 1.010–1.043; p=0.002), QTc interval (OR: 0.988; 95% CI: 0.979–0.997; p=0.009), and left ventricular ejection fraction (OR: 0.922; 95% CI: 0.859–0.989; p=0.023) were independently associated with greater EAT thickness.

CONCLUSION
Echocardiographic end-diastolic EAT thickness on the free wall of the right ventricle was associated with Pd and QTc in patients with normal coronary arteries.

Keywords: Corrected QT interval, epicardial adipose tissue; P-wave dispersion.

How to cite this article
Alaa Quisi, Serhat Emre Şentürk, Hazar Harbalıoğlu, Ahmet Oytun Baykan. The relationship between echocardiographic epicardial adipose tissue, P-wave dispersion, and corrected QT interval. Turk Kardiyol Dern Ars. 2018; 46(6): 471-478

Corresponding Author: Alaa Quisi, Türkiye
© Copyright 2018 Archives of the Turkish Society of Cardiology
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