Can ischemia-modified albumin help in differentiating myocardial perfusion scintigraphy results? [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2016; 44(5): 380-388 | DOI: 10.5543/tkda.2016.99148

Can ischemia-modified albumin help in differentiating myocardial perfusion scintigraphy results?

Hüseyin Ede1, Barış Yaylak2, Süleyman Akkaya2, Seyhan Karaçavuş3, Ayşe Yeşim Göçmen4, Ali Rıza Erbay1
1Bozok University, Faculty Of Medicine, Department Of Cardiology, Yozgat, Turkey
2Diyarbakır Gazi Yaşargil Education And Research Hospital, Cardiology Clinic, Diyarbakır, Turkey
3Bozok University, Faculty Of Medicine, Department Of Nuclear Medicine, Yozgat, Turkey
4Bozok University, Faculty Of Medicine, Department Of Biochemistry, Yozgat, Turkey


OBJECTIVE
Myocardial perfusion scintigraphy (MPS) is a diagnostic tool commonly used to detect significant coronary lesion. However equivocal, false negative or positive results can be yielded. Controversial findings regarding the role of ischemia-modified albumin (IMA) in MPS evaluation persist. The aim of the present study was to examine the role of serum IMA in the assessment of MPS results.

METHODS
MPS using technetium (99mTc) sestamibi and transthoracic echocardiography was performed on 62 consecutive subjects prospectively enrolled. Exercise treadmill test (ETT) with modified Bruce protocol was used to induce coronary ischemia. During MPS performance, blood samples for serum IMA were obtained at 3 times: at pre-exercise, at the peak of ETT, and 6 hours after ETT. Patients were classified into 3 groups according to MPS results (normal, equivocal, and ischemia).

RESULTS
Sixty-two patients (23 normal, 20 equivocal, 19 with ischemia) were included. Pre- and peak-exercise IMA values were similar among the groups (p=0.706 and 0.904). Postexercise IMA values of the normal and equivocal groups were similar (p=0.733), while that of the ischemia group was significantly higher than the values of either the normal (p<0.001) or equivocal groups (p<0.001). ΔIMA (the difference between post-exercise and peak-exercise IMA) of the ischemia group was significantly higher than that of either the normal (p<0.001) or equivocal groups (p<0.001).

CONCLUSION
Serum IMA was found to be significantly increased in cases of ischemia on MPS. Subjects with normal and equivocal MPS had a similar pattern during the test. IMA may be used in differentiation of equivocal results from false positive results.

Keywords: Ischemia modified albumin, coronary arter disease, myocardial perfusion scintigraphy.

How to cite this article
Hüseyin Ede, Barış Yaylak, Süleyman Akkaya, Seyhan Karaçavuş, Ayşe Yeşim Göçmen, Ali Rıza Erbay. Can ischemia-modified albumin help in differentiating myocardial perfusion scintigraphy results?. Turk Kardiyol Dern Ars. 2016; 44(5): 380-388

Corresponding Author: Hüseyin Ede, Türkiye
© Copyright 2019 Archives of the Turkish Society of Cardiology
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