Turk Kardiyol Dern Ars. Ahead of Print: TKDA-94770 | DOI: 10.5543/tkda.2018.94770
In determining cut-off values for increased carotid intima-media thickness age should be considered
Ayse Selcan Koc1
, Hilmi Erdem Sumbul21
University of Health Sciences - Adana Health Practice and Research Center, Department of Radiology2
University of Health Sciences - Adana Health Practice and Research Center, Department of Internal Medicine
OBJECTIVE Regardless of age and gender, the guidelines are considered to be > 0.9mm as the cut-off value for increased carotid intima-media thickness (C-IMT). In our study, we planned to investigate the effects of age and gender on C-IMT and cut-off values for C-IMT in different age groups.
METHODS 664 patients with a C-IMT measurement of at least 1 cardiovascular risk factor between 20-90 years of age were included. Common and internal C-IMT (CC-IMT and IC-IMT) measurements were obtained from carotid ultrasonography (USG). Patients, included in the study were divided into 5 groups as Group-I(20-40), Group-II(41-50), Group-III(51-60), Group-IV(61-70) and Group-V(>70).
RESULTS CC-IMT and IC-IMT values significantly increased from Group-I to Group-V. Group I-II-II-IV-V showed median CC-IMT values of 0.70-0.70-0.75-0.75-0.85mm, respectively. IC-IMT median value was 0.60-0.65-0.70-0.70-0.80mm, respectively. In all groups, the median CC-IMT value was found to be 50μm higher than the median IC-IMT value. Only CC-IMT values were significantly different in males (0.80±0.20mm vs. 0.76±0.19mm, p=0.020). Increased age, hypertension (HT), smoking, hyperlipidemia, systolic-diastolic blood pressures and body mass index were found to be associated with increased C-IMT. Increased C-IMT was independently associated with age and HT presence. It was found that age increases every-1 decade and the presence of HT determines the presence of increased C-IMT by 44% and 53%, respectively.
CONCLUSION C-IMT significantly increases with age. For this reason, new age-appropriate cut-off values are needed for C-IMT. In addition, CC-IMT values are approximately 50μm higher than IC-IMT measurements in all age groups and CC-IMT should be reported in USG reports.
Advanced age, carotid intima-media thickness, cut-off values
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Corresponding Author: Ayse Selcan Koc, Türkiye