Clinical Significance of Increased Troponin Levels in Clinical Events Other than Acute Coronary Syndromes [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2004; 32(8): 571-580

Clinical Significance of Increased Troponin Levels in Clinical Events Other than Acute Coronary Syndromes

Egemen DUYGU1, Nalan KAHRAMAN1, Seçkin PEHLİVANOĞLU1, Zeki ÖNGEN1

Cardiac troponins are the regulatory proteins of thin actin filaments in myocardium. Troponin T and I are markers with high specificity and sensitivity for myocardial injury. Recently, they have been accepted as the standard markers for the diagnosis and risk statification in patients with acute coronary syndromes. However, serum cardiac troponin levels also rise in events other than acute coronary syndromes. This may lead to misdiagnosis and unnecessary invasive procedures. High levels of cardiac troponins in acute coronary syndromes are predictors of increased incidence mortality and morbidity. Raised cardiac troponin levels have also prognostic significance in patients with heart failure, sepsis, renal failure and pulmonary embolism. Troponin release from myocardium shows permanent or transient injury. This injury can be caused by many events like ischemia, inflammation, infection, toxins or increased wall strain. This review briefs the structure, mechanism of release, and biochemical analysis of cardiac troponins. The clinical events other than acute coronary syndromes that raise blood troponin T and I levels are described in addition to the probable mechanisms, clinical impact of that elevation and diagnostic decision. (Türk Kardiyol Dern Arş 2004; 32: 571-580)

Keywords: Acute coronary syndrome, renal failure, heart failure, pulmonary embolism, troponins

How to cite this article
Egemen DUYGU, Nalan KAHRAMAN, Seçkin PEHLİVANOĞLU, Zeki ÖNGEN. Clinical Significance of Increased Troponin Levels in Clinical Events Other than Acute Coronary Syndromes. Turk Kardiyol Dern Ars. 2004; 32(8): 571-580
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