Can flecainide totally eliminate bidirectional ventricular tachycardia in pediatric patients with Andersen-Tawil Syndrome? [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-77856 | DOI: 10.5543/tkda.2017.77856

Can flecainide totally eliminate bidirectional ventricular tachycardia in pediatric patients with Andersen-Tawil Syndrome?

Yakup Ergül1, Senem Özgür1, Sertaç Hanedan Onan2, Volkan Tuzcu3
1Mehmet Akif Ersoy Cardiovascular Research and Training Hospital, Pediatric Cardiology and Arrhythmia Department, Istanbul, Turkey
2Bagcilar Training and Research Hospital, Pediatric Cardiology Department,Istanbul, Turkey
3Medipol University Hospital, Pediatric Cardiology and Arrhythmia Department, Istanbul, Turkey

Andersen-Tawil syndrome is a disorder that causes episodes of muscle weakness (periodic paralysis), changes in heart rhythm, and developmental abnormalities. QT prolongation and ventricular arrhythmias including bidirectional ventricular tachycardia (VT) and polymorphic VT may occur. About 60 percent of all cases of the disorder, is caused by mutations in the KCNJ2 gene. A 13-year-old female patient was referred to our hospital for frequent premature ventricular contractions. The patient was thought to be Andersen Tawil, due to dysmorphic findings, ECG changes, and periodic muscle weakness and diagnosis is genetically confirmed. Beta blocker was initiated as a first-line treatment for bidirectional ventricular tachycardia and polymorphic frequent premature ventricular contractions. Despite proper treatment, ventricular tachycardia attacks could not be controlled. Whereupon Flecainide was added to treatment. Number of premature ventricular contractions dramatically reduced with flecainide. Moreover VT attacks completely disappeared. This patient is one of the rare Andersen Tawil Syndrome in our country. In this article, it is described that successful management of rhythm disturbance in patient with Andersen Tawil Syndrome.

Keywords: Flecainide, bidirectional ventricular, tachycardia, long QT

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Corresponding Author: Yakup Ergül, Türkiye
© Copyright 2018 Archives of the Turkish Society of Cardiology
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