ISSN 1016-5169 | E-ISSN 1308-4488
pdf
Major depressive disorder in chronic heart failure patients: Does silent cerebral infarction cause major depressive disorder in this patient population? [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(6): 505-512 | DOI: 10.5543/tkda.2015.77753

Major depressive disorder in chronic heart failure patients: Does silent cerebral infarction cause major depressive disorder in this patient population?

Güliz Kozdağ1, İrem Yaluğ2, Nagihan İnan3, Gökhan Ertaş4, Macit Selekler5, Hüseyin Kutlu2, Ayşe Kutlu5, Ender Emre1, Metin Çetin6, Dilek Ural1
1Kocaeli University, Faculty of Medicine, Department of Cardiology, Kocaeli, Turkey,
2Kocaeli University, Faculty of Medicine, Department of Psychiatry, Kocaeli, Turkey,
3Kocaeli University, Faculty of Medicine, Department of Radiology, Kocaeli, Turkey
4Dr. Siyami Ersek Thoracic And Cardiovascular Surgery Training And Research Hospital, Department Of Cardiology, İstanbul, Turkey
5Kocaeli University, Faculty of Medicine, Department of Neurology, Kocaeli, Turkey
6Merkez Hospital, Department of Cardiology, Kocaeli, Turkey


OBJECTIVE
Depression frequently occurs in patients with heart failure as similar pathophysiological mechanisms present in both these diseases. Patients with dilated cardiomyopathy (DCM) have a high incidence of clinically asymptomatic silent cerebral infarction (SCI). This study aimed to evaluate the relation between SCI and major depressive disorder (MDD), and between MDD and clinical and biochemical parameters in DCM patients.

METHODS
Patients with ischemic and non-ischemic DCM who had chronic heart failure (CHF) (39 male, 10 female, age 60±10 years) were included in the study. Mean patient ejection fraction (EF) was 34±10%. Patients had no localized neurological symptoms or stroke history. The etiology of DCM was ischemic in 40 and non-ischemic in 9 patients. Twentyfive age-matched healthy volunteers served as a control group for comparison of SCI and MDD prevalence.

RESULTS
Patients had mild to severe CHF symptoms. Prevalence of SCI and MDD was significantly higher in patients with DCM than in the control group; 63% vs 8%; p<0.001, and 52% vs 20%; p<0.001 respectively. Patients with SCI had a higher prevalence of MDD than patients without SCI in DCM (61% vs 27%, p=0.02).

CONCLUSION
CHF patients have an increased prevalence of SCI and MDD. Patients with SCI have a higher prevalence of MDD compared to patients without SCI in CHF.

Keywords: Cardiomyopathy, chronic heart failure, major depressive disorder, silent cerebral infarction

How to cite this article
Güliz Kozdağ, İrem Yaluğ, Nagihan İnan, Gökhan Ertaş, Macit Selekler, Hüseyin Kutlu, Ayşe Kutlu, Ender Emre, Metin Çetin, Dilek Ural. Major depressive disorder in chronic heart failure patients: Does silent cerebral infarction cause major depressive disorder in this patient population?. Turk Kardiyol Dern Ars. 2015; 43(6): 505-512

Corresponding Author: Ender Emre, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 Archives of the Turkish Society of Cardiology



Kare Publishing is a subsidiary of Kare Media.