Turk Kardiyol Dern Ars. Ahead of Print: TKDA-77292 | DOI: 10.5543/tkda.2019.77292
Short term mortality of patients with Saddle Pulmonary Embolism: A single center study
, Samad Ghaffari1
, Hamid Rajebi2
, Hadiseh Kavandi1
, Elnaz Javanshir1
, Golshan Fahimi3
, Sahar Ghodratizadeh41
Cardiovascular Research Center, Tabriz University of Medical science, Tabriz, Iran2
Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA3
Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.4
School of medicine, Urmia University of Medical Science, Urmia, Iran
BACKGROUND Although hemodynamic instability has been identified as the most established mortality predictor of acute pulmonary embolism (PE), the debate is still open about prognostic significance of saddle pulmonary embolism (SPE). In this study, we aimed to determine in-hospital mortality rate of SPE patients diagnosed via computed tomographic pulmonary angiography (CTPA) and compare them with non-SPE.
METHODS Presence of SPE on CTPA was used to classify 492 consecutive patients into SPE and non-SPE groups. Different features were compared between the two groups, after which independent predictors of in-hospital mortality rate of acute PE were identified.
RESULTS A total of 70 patients (14.2%) had SPE. In univariate analysis, SPE group had a higher in-hospital mortality rate, as well as lower O2 saturation and systolic and diastolic blood pressure (BP) in comparison with the non-SPE group (all p values < 0.005). Multivariate analysis revealed SPE as an independent predictor of in-hospital mortality in acute PE patients (OR=9.21, 95% CI = 3.40-24.89, p value < 0.001).
CONCLUSION Our study demonstrated that SPE has a statistically significant importance in predicting in-hospital mortality rate and in-hospital adverse events of PE patients, which has been inconsistent with many prior studies.
saddle pulmonary embolism, in-hospital mortality, prognosis, mortality.
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Corresponding Author: Reza Hajizadeh, Iran