Influence of Smoking Habits on Acute Outcome of Revascularization of CTO [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-75133 | DOI: 10.5543/tkda.2018.75133

Influence of Smoking Habits on Acute Outcome of Revascularization of CTO

Jan-erik Guelker1, Christian Blockhaus1, Ruben Jansen1, Johannes Stein1, Julian Kürvers1, Mathias Lehmann1, Knut Kröger2, Alexander Bufe1
1Heartcentre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany
2Department of Angiology, Helios Clinic Krefeld, Krefeld, Germany


Percutaneous coronary intervention (PCI) of total chronic total occlusion (CTO) still remains a major challenge in interventional cardiology. The exact toxic components of cigarette smoke and the mechanisms involved in smoking-related cardiovascular dysfunction are largely unknown, but it increases inflammation, thrombosis, and oxidation of low-density lipoprotein cholesterol. There is only insignificant knowledge reported in the literature about the influence of smoking habits on acute outcome in CTO-PCI.


Between 2012-2017 we included 559 patients. They underwent PCI for at least one CTO. Antegrade and retrograde CTO techniques were applied. The Shapiro-Wilk test was used to test for normality of distribution. Continuous variables were tested for differences with the Kruskal–Wallis-test or the Mann–Whitney-U test as appropriate. Categorical variables were tested with Fisher's exact test.


Non-smokers were older than smoking patients (65.3±10.3years vs. 58.3±9.2years;p=<0.001). The mean age oft he cohort was 62.1 years (±10.5). Smokers were more often male (85.7% vs. 79.7%;p=0.074), suffered from longer lesion length (36.1±17.5mm vs. 39.1±17.2mm;p=0.023) and needed therefore longer stents (64.2±26.5mm vs. 69.0±28.0mm;p=0.084). The success rates were comparable for smokers and non-smokers. In-hospital procedural complications were rare and showed no difference.


Our retrospective study suggests that there exists no significant association between smoking and non-smoking patients. Nevertheless they suffer from longer lesion length and needed longer stents.

Keywords: chronic total occlusion, percutaneous coronary intervention, smoking habits,

How to cite this article

Corresponding Author: Jan-erik Guelker, Germany
© Copyright 2018 Archives of the Turkish Society of Cardiology
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