Disseminated Adenovirus Infection in Heart and Kidney Transplant [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-74957 | DOI: 10.5543/tkda.2017.74957

Disseminated Adenovirus Infection in Heart and Kidney Transplant

Jack Xu1, Keval V Patel2, Melroy Dsouza3, Jesus Almendral2, Kanika Mody2, Deepa Iyer2
1Internal Medicine, Rutgers - Robert Wood Johnson University Hospital, New Brunswick, NJ, USA
2Cardiology, Rutgers - Robert Wood Johnson University Hospital, New Brunswick, NJ, USA
3Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA

We report a case of disseminated adenovirus infection in a heart-kidney transplant recipient who was successfully treated with cidofovir. There are several reports of adenovirus infections in adult solid organ transplant recipients and the prognosis is usually poor with mortality rates of 40-60%. Severe disseminated adenovirus infections have been associated with increased risk of adverse transplant events such as rejection, ventricular dysfunction, allograft vasculopathy, graft loss, and need for re-transplantation. Patient’s lack of clinical improvement, onset of hemorrhagic cystitis and AKI factored into our decision to hold his immunosuppressive agents and start an antiviral agent. We believe that it is important to suspect adenovirus in transplant patients when they do not respond to antibiotics and cultures are negative. Early diagnosis and treatment are critical to improving outcomes in immunocompromised patients.

Keywords: disseminated adenovirus, heart and kidney transplant, transplant recipient

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Corresponding Author: Jack Xu, United States
© copyright 2018 Archives of the Turkish Society of Cardiology
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