Turk Kardiyol Dern Ars. Ahead of Print: TKDA-72809 | DOI: 10.5543/tkda.2018.72809
Idiopathic dilated cardiomyopathy in children: Prognostic indicators
Mehmet Emre Arı1
, Tamer Yoldaş2
, Utku Arman Örün2
, Selmin Karademir21
Yenimahalle Training and Research Hospital,Ankara, Turkey2
Dr. Sami Ulus Obstetrics and Gynecology, Childrens Health and Diseases Training and Research Hospital, Ankara, Turkey
Dilated cardiomyopathy(DCM) which has poor prognosis is a disorder with left ventricular dysfunction and heart failure. Etiology is still unclear despite diagnostic and therapeutic developments. In this study, we evaluated the factors affecting the life span of our idiopathic DCM patients.
Seventy-nine patients with diagnosis of idiopathic DCM were evaluated retrospectively between October-2005 and October-2017. Demographic characteristics, clinical information, left ventricular functions, treatment and follow-up of the patients were reviewed by hospital records. Affecting prognosis factors were assessed such as age, gender, parental consanguinity, cardiomegaly on telecardiography, reduced ejection fraction(EF) and shortening fraction(SF), degree of mitral regurgitation, and detected intracardiac thrombosis.
The ages of patients were 20±60months, and the male/female ratio was 1.02/1. The patients most frequently presentation were heart failure (n=59,74.7%) symptoms and signs. The most common physical examination findings were murmur(n=53,67.1%) and tachycardia(n=48,60.8%). There was cardiomegaly on telecardiography in 73.4% of patients. EF and SF values were 35.7±12.6% and 17.3±6.5% respectively. In 42(53.2%) patients had grade-2 and above mitral regurgitation. The duration of follow-up was between 1-156months (20±34.9). Intracardiac thrombosis was detected in four(5.1%) patients. The mortality rate was found 36.7%. When prognostic factors were compared according to survival time, it was seen that survival time was shorter at parental consanguinity, low EF, and cardiomegaly on telecardiography.
The most important negative markers of affecting the survival time of DCM patients are parental consanguinity, detected cardiomegaly on telecardiography, reduced EF levels.
Dilated cardiomyopathy, prognosis, children
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Corresponding Author: Mehmet Emre Arı, Türkiye