Turk Kardiyol Dern Ars. Ahead of Print: TKDA-72436 | DOI: 10.5543/tkda.2018.72436
Hematologic Indices in Renovascular Hypertension: A Propensity Score Matching Analysis
Ahmet Seyfeddin Gurbuz1
, Semi Ozturk21
Department Of Cardiology, Necmettin Erbakan University Meram Faculty Of Medicine, Konya, Turkey2
Department Of Cardiology, Haseki Education And Research Hospital, Istanbul, Turkey
OBJECTIVES We assessed difference of various hematologic blood count parameters including neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with renovascular (RVH) and essential hypertension (EH).
METHODS We performed a propensity score analysis to match 51 patients with RVH and 173 patients with EH. After matching, 49 pairs of patients were compared.
Result: Before matching, patients with RVH had significantly higher values of NLR [1.35 (1.14 - 1.76) vs. 1.05 (0.81 - 1.3)] (p<0.001) and MPV [8.7 (8.3 - 9.5) vs. 8.4 (7.3 - 9.2)] (p: 0.002). After propensity score matching (49 vs 49 patients), age, sex, atherosclerosis risk factors, frequency of atherosclerosis, medications used were similar between groups. Additionally, NLR remained significantly increased in patients with RVH [1.00 (0.76- 1.40) vs 1.35 (1.15 - 1.75)](p: <0.001). MPV did not differ between groups. NLR was the only parameter independently associated with RVH in multivariate logistic regression (OR=5.563, 95% CI =2.089-14.814, p: <0.001). In ROC curve analysis, NLR >1.16 predicted RVH with a sensitivity of 72% and a specificity of 60% [area under curve (AUC) =0.724, 95% CI =0.624-0.823, p: <0.001]
DISCUSSION The present study showed that NLR, which is a simple and clinical parameter of inflammation, is increased in patients with RVH.
essential hypertension, renal artery stenosis, neutrophil to lymphocyte ratio, mean platelet volume
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Corresponding Author: Ahmet Seyfeddin Gurbuz, Türkiye