Clinical Investigations Serum Troponin T in Acute Myocardial Infarction [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1994; 22(1): 12-15

Clinical Investigations Serum Troponin T in Acute Myocardial Infarction

Lale TOKGÖZOĞLU1, Erdem ORAM1, Kudret AYTEMİR1, Hakan ORAL1, Cumhur ÖZKUYUMCU1

Troponin T (Tn-T) is a cardiospecific antigen released from the damaged myocardium. The serum levels of Tn-T in healthy individuals are negligible. These properties suggested that Tn-T might be useful in the diagnosis of AMI. To evaluate the release profile of Tn-T and compare it with CK-MB levels, 15 patients who were hospitalized in the Coronary Care Unit of the Hacettepe University hospital with chest pain and typical ECG changes of AMI were studied (10 male, 5 female, age 35-68; mean age 54). Only patients who did not receive thrombolytic therapy were evaluated to study the natural release curve of Tn-T. Serum levels of Tn-T and CK-MB Tn-T and CK-MB levels increased within a few hours. Tn-T levels peaked at 24 hours, followed by a plateau and started to decrease on the 4th day. CK-MB levels peaked at 12 hours. The sensitivity of Tn-T at 6, 12, 48, hours and 7 days was 54, 73, 100, 86 %, respectively. The sensitivity of CK-MB at the same time intervals was 54, 86, 100, 60, 0 % respectively. Both medhods were useful for the early diagnosis of acute myocardial infarction (p>0.05). However, Tn-T was more sensitive after 36 hours (p<0.05). We concluded that Tn-T levels start to increase within a few hours similar to CK-MB but stay elevated for a longer period of time permitting a longer diagnostic window. Although Tn-T cannot replace CK-MB in the early diagnosis of AMI, it will be a helpful alternative in patients with borderline CK-MB levels or those who are first seen later in the course of myocardial infarction.

How to cite this article
Lale TOKGÖZOĞLU, Erdem ORAM, Kudret AYTEMİR, Hakan ORAL, Cumhur ÖZKUYUMCU. Clinical Investigations Serum Troponin T in Acute Myocardial Infarction. Turk Kardiyol Dern Ars. 1994; 22(1): 12-15
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