Turk Kardiyol Dern Ars. 2014; 42(1): 29-34 | DOI: 10.5543/tkda.2014/52959
Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis
, Murat Akkoyun1
, Alper Buğra Nacar1
, İmran Dirnak1
, Gözde Yıldırım Çetin2
, Makbule Nur Yıldırım3
, Cemil Zencir3
, Kayıhan Karaman3
, Mustafa Çetin3
, Mehmet Sayarlıoğlu21
Department of Cardiology, Kahramanmaraş Necip Fazil State Hospital, Kahramanmaraş2
Department of Cardiology, Kahramanmaras Sutcu Imam University Faculty of Medicine, Kahramanmaras3
Department of Rheumatology, Kahramanmaras Sutcu Imam University Faculty of Medicine, Kahramanmaras
OBJECTIVE Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that inreased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. The aim of this study was to evaluate ventricular repolarization by using Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis (RA), and to assess the relation with inflammation.
STUDY DESIGN Ninety-six patients with RA and and 50 controls were included. From the 12-lead electrocardiogram Tp-e interval and Tp-e/QT ratio were measured. Blood samples were taken for erythrocyte sedimentation rate (ESR) and plasma levels of C-reactive protein (CRP). These parameters were compared between groups. The relationship between ventricular repolarization and inflammation was assessed by Pearson correlation coefficients.
RESULTS Tp-e interval and Tp-e/QT ratio were increased in RA patients compared to the controls (72.6±8.2 vs 66.4±8.5 milliseconds, 0.20 ± 0.02 vs 0.18 ± 0.02; P<0.001 and P<0.001, respectively). Tp-e interval was significantly correlated with CRP, ESR, and disease acticity score (DAS-28) (r=0.56, P<0.001, r=0.57, P<0.001, and r=0.29, P=0.02, respectively). Tp-e/QT ratio was also correlated with CRP, ESR, and DAS-28 score (r=0.43, P<0.001, r=0.53, P<0.001, and r=0.25, P=0.03, respectively).
CONCLUSIONS Increased frequency of ventricular arrhythmias may explain by increased indexes of ventricular repolarization and their relationship with inflammation in RA patients.
electrocardiogram, inflammation, ventricular arrhythmogenesis, ventricular repolarization
How to cite this article
Gurkan Acar, Murat Akkoyun, Alper Buğra Nacar, İmran Dirnak, Gözde Yıldırım Çetin, Makbule Nur Yıldırım, Cemil Zencir, Kayıhan Karaman, Mustafa Çetin, Mehmet Sayarlıoğlu. Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis. Turk Kardiyol Dern Ars. 2014; 42(1): 29-34
Corresponding Author: Gurkan Acar, Türkiye