ISSN 1016-5169 | E-ISSN 1308-4488
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Does accompanying metabolic syndrome contribute to heart dimensions in hypertensive patients? [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2008; 36(7): 446-450

Does accompanying metabolic syndrome contribute to heart dimensions in hypertensive patients?

Mehmet Uzun1, Cem Köz2, Mustafa Yıldırım2, Ata Kırılmaz1, Mehmet Yokusoglu2, Fethi Kılıçaslan1, Eralp Ulusoy1, Oben Baysan2, Cemal Sağ2, Bekir Sıtkı Cebeci1
1Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of Cardiology, Istanbul, Turkey
2Gulhane Military Medical Academy, Department of Cardiology, Ankara, Turkey


OBJECTIVES
Metabolic syndrome (MetS) is associated with increased risk for cardiovascular events. We evaluated heart dimensions in hypertensive patients with MetS.

STUDY DESIGN
The study included 75 hypertensive patients (34 males, 41 females; mean age 51±9 years) without coronary artery disease. Patients were evaluated in two groups depending on the presence or absence of MetS. Age and gender-matched 20 healthy subjects (9 males, 11 females; mean age 50±5 years) comprised the control group. The diagnosis of MetS was based on the presence of at least three of five MetS criteria. Hypertension was defined as arterial blood pressure exceeding 140/85 mmHg on three consecutive measurements or the use of antihypertensive drugs. Echocardiographic measurements included interventricular septal thickness, left ventricular internal diameter, posterior wall thickness, aortic diameter, left atrial diameter, relative wall thickness, and left ventricular mass.

RESULTS
Metabolic syndrome was present in 32 hypertensive patients (42.7%; 18 males, 14 females). The mean number of MetS criteria was 2.6±1.0 in the hypertensive group. Compared to the control group, patients with or without MetS exhibited significantly increased interventricular septum and posterior wall thickness, left atrial diameter, relative wall thickness, and left ventricular mass (p<0.05). The only significant difference between the two patient groups was that MetS was associated with a greater left atrial diameter (p=0.019). Left atrial diameter was correlated with the number of MetS criteria (r=0.51; p<0.001).

CONCLUSION
Left ventricular dimensions are not influenced by MetS. Rather than MetS, hypertension is primarily responsible for changes in left ventricular dimensions. However, left atrial enlargement is more prominent in patients with MetS, suggesting that each MetS criterion contributes to left ventricular diastolic dysfunction.

Keywords: Blood pressure, echocardiography, heart ventricles, hypertension; metabolic syndrome X

How to cite this article
Mehmet Uzun, Cem Köz, Mustafa Yıldırım, Ata Kırılmaz, Mehmet Yokusoglu, Fethi Kılıçaslan, Eralp Ulusoy, Oben Baysan, Cemal Sağ, Bekir Sıtkı Cebeci. Does accompanying metabolic syndrome contribute to heart dimensions in hypertensive patients?. Turk Kardiyol Dern Ars. 2008; 36(7): 446-450

Corresponding Author: Mehmet Yokusoglu, Türkiye
Manuscript Language: Turkish


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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