Turk Kardiyol Dern Ars. 2013; 41(3): 199-206 | DOI: 10.5543/tkda.2013.42375
Elevated red blood cell distribution width in healthy smokers
, Erdal Aktürk2
, Hasan Korkmaz1
, İsa Sincer3
, Mücahid Yılmaz1
, Kenan Erdem1
, Ahmet Çelik1
, Ramazan Özdemir21
Department of Cardiology, Elazig Training and Research Hospital, Elazig, Turkey2
Department of Cardiology, Inonu University Faculty of Medicine, Malatya, Turkey3
Department of Cardiology, Dr. Ersin Aslan State Hospital, Gaziantep, Turkey
OBJECTIVES Red blood cell distribution width (RDW) has been reported to be a marker of morbidity and mortality for some cardiovascular and pulmonary diseases. We aimed to evaluate RDW values in otherwise healthy smokers.
STUDY DESIGN Two hundred and twenty consecutive subjects with current smoking and 230 age- and gender-matched healthy subjects without smoking history were enrolled. Number of cigarettes smoked per day and duration of smoking, evaluated as pack years, were recorded. Complete blood count, high-sensitivity C-reactive protein (hs-CRP) levels and lipid profile were analyzed in all study participants.
RESULTS The mean RDW values were higher in smokers than in nonsmokers (13.9±1.2 vs. 13.1±0.8, p<0.0001). The mean leukocyte count, mean platelet volume and hs-CRP levels were also significantly greater in smokers when compared to nonsmokers (8440±1.750 vs. 7090±1550, p<0.0001; 8.7±0.8 fL vs. 8.3±0.6 fL, p<0.0001; 2.42±0.53 mg/L vs. 1.46±0.52 mg/L, p<0.0001, respectively). Significant positive correlations between RDW and number of cigarettes smoked per day and between RDW and duration of smoking were identified (r=0.565 and r=0.305, respectively).
CONCLUSION Elevated RDW is associated with cigarette smoking and may be a useful indicator of inflammatory activity in smokers.
Biological markers, blood flow velocity; C-reactive protein; coronary circulation; erythrocyte indices; inflammation; smoking, cigar.
How to cite this article
Ertuğrul Kurtoğlu, Erdal Aktürk, Hasan Korkmaz, İsa Sincer, Mücahid Yılmaz, Kenan Erdem, Ahmet Çelik, Ramazan Özdemir. Elevated red blood cell distribution width in healthy smokers. Turk Kardiyol Dern Ars. 2013; 41(3): 199-206
Corresponding Author: Ertuğrul Kurtoğlu, Türkiye