ISSN 1016-5169 | E-ISSN 1308-4488
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Relationship between red cell distribution width and contrast-induced nephropathy in patients who underwent primary percutaneous coronary intervention [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2015; 43(7): 613-620 | DOI: 10.5543/tkda.2015.37941

Relationship between red cell distribution width and contrast-induced nephropathy in patients who underwent primary percutaneous coronary intervention

Dursun Çayan Akkoyun1, Aydın Akyüz1, Ömer Kurt2, Bülent Bilir3, Şeref Alpsoy1, Niyazi Güler1
1Department of Cardiology, Namik Kemal University Faculty of Medicine, Tekirdag,turkey
2Department of Urology, Namik Kemal University Faculty of Medicine, Tekirdag,turkey
3Department of Internal Medicine, Namik Kemal University Faculty of Medicine, Tekirdag,turkey


OBJECTIVE
This study evaluated the relationship between contrast-induced nephropathy (CIN) and red cell distribution width (RDW) in patients who underwent primary percutaneous coronary intervention (PCI).

METHODS
A total of 359 patients with ST elevation myocardial infarction (STEMI) who had undergone primary PCI were included in the study. An increase of 25% in serum creatinine value after 48 h, or an increase of >0.5 mg/dL in the basal value was defined as CIN.

RESULTS
Of the patients included in the study, 49 (13.8%) developed CIN. Compared to the CIN-negative group, CINpositive patients had increased RDW values (16.9±2.00 and 14.8±2.14 respectively, p<0.001). The latter were also older patients, and had increased age rates of diabetes mellitus, baseline creatinine, Δ-creatinine and amount of contrast media were higher and left ventricular ejection fraction and baseline glomerular filtration rate (GFR) were lower in the CIN-positive group than in the CIN-negative group. A statistically weak correlation was found between RDW and change in creatinine levels (Δ-creatinine) (r=0.250, p=0.002). Diabetes mellitus (odds ratio [OR]: 3.252, 95% CI=1.184-8.951, p=0.022), high RDW (OR: 1.716, 95% CI=1.363–2.157, p<0.001), baseline low GFR (OR: 0.941, 95% CI=0.925– 0.971, p<0.001), Δ-creatinine (OR: 1.197, 95% CI=1.061- 2.986, p=0.006) and increased amount of contrast media (OR: 1.187, 95% CI=1.048–3.02, p=0.001) used were observed as independent predictors of CIN.

CONCLUSION
The study found diabetes mellitus, high RDW, basal low GFR, Δ-creatinine and increased contrast amount used to be the independent predictors of CIN in STEMI patients who underwent PCI.

Keywords: Angioplasty, balloon, coronary, contrast media; contrast induced nephropathy; myocardial infarction; percutaneous transluminal coronary angioplasty; red cell distribution width

How to cite this article
Dursun Çayan Akkoyun, Aydın Akyüz, Ömer Kurt, Bülent Bilir, Şeref Alpsoy, Niyazi Güler. Relationship between red cell distribution width and contrast-induced nephropathy in patients who underwent primary percutaneous coronary intervention. Turk Kardiyol Dern Ars. 2015; 43(7): 613-620

Corresponding Author: Dursun Çayan Akkoyun, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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