Effect of Nitrovasodilators on Nitric oxide-cyclic GMP Pathway during Cardiopulmonary Bypass [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 1998; 26(9): 534-537

Effect of Nitrovasodilators on Nitric oxide-cyclic GMP Pathway during Cardiopulmonary Bypass

Bülent TÜNERİR1, Yavuz BEŞOĞUL1, Turan YAVUZ1, Abdelmajeed ALEqaidat1, Recep ARSLAN1, Behçet SEVİN1, Tuğrul KURAL1

This study, aimed to evaluate the effect of nitrovasodilators on the pathway of nitric oxideguanosine monophosphate (cGMP) administrated preoperatively to patients under going coronary artery bypass grafting under cardiopulmonary bypass (CPB). Of 30 cases who underwent coronary artery bypass grafting, 15 were administrated isosorbieder dinitrate preoperatively, and 15 cases with out angina pectorisa were weaned from nitrated drugs and remained as a control group. Before and after CPB, plasma cGMP levels of blood samples taken from coronary sinus were measured. The two groups disclosed no statistically significant difference between mean data regarding age, sex, weight, aortic cross clamp time, and CPB time.
RESULTS
In the nitrate group, the mean plasma cGMP !eve! before CPB was measured as 5.76 ± 0.57 pmol/ml, and that of the control group was measured as 2.78±0.3 pmol/ml, while after CPB the mean plasma cGMP !eve! was 7.77±0.30 prnol/mJ in the nitrate group and 3.66±0.20 in the control group (pKeywords: Nitric oxide cy lic-GMP cardiopulmonary by-pass, nitrovasodilators


How to cite this article
Bülent TÜNERİR, Yavuz BEŞOĞUL, Turan YAVUZ, Abdelmajeed ALEqaidat, Recep ARSLAN, Behçet SEVİN, Tuğrul KURAL. Effect of Nitrovasodilators on Nitric oxide-cyclic GMP Pathway during Cardiopulmonary Bypass. Turk Kardiyol Dern Ars. 1998; 26(9): 534-537
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