Turk Kardiyol Dern Ars. Ahead of Print: TKDA-36151 | DOI: 10.5543/tkda.2018.36151
Relationship between Monocyte/High-Density Lipoprotein Ratio and Selvester QRS Score in Patients with STEMI
, Mustafa Çetin, Serdar Turkmen, Hakan Tasolar, Erdal Aktürk
Adiyaman University Education and Research Hospital
OBJECTIVE The ratio of monocytes to high-density lipoprotein (MHR) has recently been recommended as a new prognostic factor in cardiovascular disease. Studies have documented the value of the Selvester QRS score for prediction of prognosis of ST-elevation myocardial infarction (STEMI). However, no study has examined the association between the QRS score and MHR in patients with STEMI. The present study analyzed the relationship between MHR and QRS score in patients with STEMI.
METHODS We retrospectively evaluated a cohort of 99 consecutive patients with STEMI between June and September 2016. The serial measurements of ECG, monocyte count, and lipid panels (day 1, day 2, and after discharge) were performed in all patients, following which MHR was calculated at these time points. The patients were classified into two groups based on the median values according to the estimated infarct size: QRS score < 6 and QRS score ≥ 6.
RESULTS The MHR was higher in the high QRS score group on day 1 in hospital (p = 0.001). The MHR value was associated with QRS score in univariate logistic regression analysis and was found to be an independent predictor of the QRS score (OR: 0.390, 95% CI: 0.252-0.605, p < 0.001).
CONCLUSION A higher MHR serves as an indicator of inflammation and oxidative stress and was reported to be associated with a high QRS score. In addition, we found it to be an independent predictor of such scores during follow-up in patients with STEMI.
ejection fraction, monocyte to HDL ratio, Selvester QRS score, ST elevation myocardial infarction
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Corresponding Author: Lütfü Aşkın, Türkiye