Assessment of cardiac autonomic functions by heart rate variability in patients with restless legs syndrome. [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-33896 | DOI: 10.5543/tkda.2018.33896

Assessment of cardiac autonomic functions by heart rate variability in patients with restless legs syndrome.

Abdülmelik Yıldız1, Cennet Yıldız2, Ahmet Karakurt3
1MEDICAL PARK HOSPITAL
2TEKDEN HOSPİTAL
3KAFKAS UNIVERSITY


OBJECTIVE
In the present study we aimed to investigate the cardiac autonomic effects of RLS by using heart rate variability (HRV).
Methods 35 patients with RLS and 35 healthy subjects were enrolled in the study. Severity of RLS symptoms were assessed using International Restless Legs Syndrome Study Group rating scale (IRLS). Correlation between Severity of RLS symptoms and HRV parameters were analyzed.

RESULTS
There were no statistically significant differences between the two groups with respect to age, gender, body mass index (BMI). The mean heart rate was 85±7.1 bpm in the RLS group compared to 79.6±5.5 bpm in the control group (p=0.001). SDNN, SDANN SDNN index were significantly lower in the RLS group compared to the control group (p<0.05 for all). There were no statistically significant differences between two groups in RMSSD and pNN50 values (p=0.119 and p=0.07 respectively). In patients with RLS, LF power and LF/HF ratio were significantly higher than those in control group (2248.6±245.6 vs 712.1±346.3, 10.7±3.7 vs 2.9±1.8, p<0.0001 and p<0.0001 respectively). Compared to control group, RLS group had lower values for HF power, but the difference was not statistically significant (p=0.07). Severity of RLS symptoms was negatively correlated with SDNN, SDANN index, pNN50 (r=-0.453 and p=0.009, r=-0.340 and p=0.046, r=-0.446 and p=0.007, respectively) and positively correlated with LF power (r=0.681 and p<0.0001).

CONCLUSION
Data of our study showed that an cardiac autonomic impairement is associated with RLS.

Keywords: Restless legs syndrome, cardiac autonomic function, heart rate variability.

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Corresponding Author: Cennet Yıldız, Türkiye
© Copyright 2018 Archives of the Turkish Society of Cardiology
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