Turk Kardiyol Dern Ars. Ahead of Print: TKDA-27708 | DOI: 10.5543/tkda.2018.27708
Can Biomarkers Help Us Understand the Pathogenesis of Coronary Slow Flow? Endocan and Omentin-I in Slow Coronary Flow Phenomena
, Remzi Sarıkaya2
, Kudret Keskin1
, Süleyman Sezai Yıldız1
, Saadet Pilten3
, Gökhan Çetinkal1
, İmran Önür2
, Kadriye Orta Kılıçkesmez11
Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital2
Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University3
Department of Biochemistery, Bagcilar Training and Research Hospital
BACKGROUND The pathophysiology of slow coronary flow (SCF) phenomenon is still unclear. The two most frequently cited mechanisms about SCF were endothelial dysfunction and subclinical diffuse atherosclerosis. In our study, we aimed to investigate that the association with SCF and serum omentin-I and endocan levels (which were thought to be associated with atherosclerosis and endothelial dysfunction).
METHODS We enrolled forty-two patients with SCF and forty-three controls with normal coronary flow based on their coronary angiograms. Serum endocan and omentin-I levels were measured and the presence of SCF was determined according to Thrombolysis in Myocardial Infarction frame count (TFC)calculations.
RESULTS Omentin-I levels were significantly lower and Endocan levels were significantly higher in patients with SCF than in controls. ROC curve analysis revealed that the sensitivity and specifity of endocan for SCF were 66% and 70% respectively (AUC: 0.760, 95% CI: 0.650.86; p < 0.001), while these values for ometin were 66% and 61% (AUC: 0.630, 95% CI: 0.510.75 p = 0.049). Multivariate logistic regression analysis revealed that high endocan levels(OR: 6.8, 95% CI: 1.849-2.439, p: 0.003, with cutoff: 2.45 ng/ml) and low omentin-I levels (OR: 3.6, 95%CI: 1.057-12.893, p: 0.041, with cutoff: 4.63 ng/ml) were independently associated with the presence of SCF. In patients with SCF while endocan levels were positively correlated with mean-TFC, omentin-I levels were negatively correlated (r: 0.44, p<0.001 ve r: - 0.22, p: 0.049; respectively).
CONCLUSION These results revealed that endocan and omentin-I might be useful biomarkers for predicting the presence and severity of SCF.
endothelial dysfunction, diffuse atherosclerosis, slow flow pathophysiology, adipokine
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Corresponding Author: Serhat Sığırcı, Türkiye