Data on prevalence of dyslipidemia and lipid values in Turkey: Systematic review and meta-analysis of epidemiological studies on cardiovascular risk factors [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2018; 46(7): 556-574 | DOI: 10.5543/tkda.2018.23450

Data on prevalence of dyslipidemia and lipid values in Turkey: Systematic review and meta-analysis of epidemiological studies on cardiovascular risk factors

Meral Kayıkçıoğlu1, Lale Tokgozoglu2, Mustafa Kılıçkap3, Hüseyin Göksülük3, Doruk Karaaslan4, Necla Özer2, Adnan Abacı5, Mehmet Birhan Yılmaz6, Cem Barçın7, Kenan Ateş8, Fahri Bayram9, Mahmut Şahin10, Dilek Ural11
1Ege University Medical School, Cardiology Department, Izmir, Turkey
2Hacettepe University Medical School, Cardiology Department, Ankara, Turkey
3Department of Cardiology, Faculty of Medicine, Ankara University, Ankara, Turkey
4Koç University Faculty of Medicine, İstanbul
5Department of Cardiology, Gazi University Faculty of Medicine, Ankara
6Department of Cardiology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
7Department of Cardiology, Gülhane Training and Research Hospital, Ankara, Turkey
8Department of Nephrology, Faculty of Medicine, Ankara University, Ankara, Turkey
9Department of Internal Medicine, Erciyes University Faculty of Medicine, Kayseri, Turkey
10Department of Cardiology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey
11Department of Cardiology, Koç University School of Medicine, Istanbul, Turkey


OBJECTIVE
Dyslipidemias, primarily hypercholesterolemia, are independent and strong predictors of cardiovascular (CV) events. The frequency of dyslipidemia is very important in terms of determining CV prevention policies. In order to determine the up-to-date frequency of CV risk factors in Turkey, a meta-analysis of the epidemiologic studies carried out in the last 15 years was performed. This article presents the results on the dyslipidemia data including hypercholesterolemia principally.

METHODS
Epidemiological studies conducted during the last 15 years that have a potential to reflect Turkey’s census sampling were searched in databases (Ovid Medline, Web of Science Core Collection, and Turkish Academic Network and Information Center [ULAKBIM]) and web pages (Ministry of Health, Turkey Statistical Institute, Turkish Society of Cardiology, Nephrology and Endocrinology Associations). A total of 7 studies including lipid data were found. Systematic review and meta-analysis of the studies with low bias score were performed. Crude values of the prevalence of hypercholeterolemia, hypertriglyceridemia and low HDL and mean lipid levels were calculated. Random effects model was used in meta-analysis.

RESULTS
The prevalence of hypercholesterolemia defined as the LDL-cholesterol >130 and/or ≥130 mg/dL, was 29.1% (95% CI 23.6–35.0) in the general population, 30.2% in females (%95 CI 24.7–36.1), and 27.8% in males (95% CI 22.3–33.6). The prevalence of low HDL-cholesterol (≤50 mg/dL for females and ≤40 mg/dL for males) was calculated as 46.1% (95% CI 42.4–49.9) in the whole group, 50.7% (95% CI 47.7–53.6) in females and 41.1% (95% CI 36.1–46.3) in males. The prevalence of hypertriglyceridemia (>150 mg/dL) was 36.5% (95% CI 30.6–42.5) in general, 32.0% (95% GA 26.6–37.8) in females and 41.3% (95% CI 34.9–47.8) in males.

CONCLUSION
Dyslipidemia constitutes a major public health problem in Turkey. In the adult population, almost 3 of 10 have hypercholesterolemia, one of 2 has a low HDL-cholesterol, and 1 of 3 has high triglycerides levels.

Keywords: Hypercholesterolemia, hypertriglyceridemia, Prevalence, meta-analysis, epidemiology, Turkey

How to cite this article
Meral Kayıkçıoğlu, Lale Tokgozoglu, Mustafa Kılıçkap, Hüseyin Göksülük, Doruk Karaaslan, Necla Özer, Adnan Abacı, Mehmet Birhan Yılmaz, Cem Barçın, Kenan Ateş, Fahri Bayram, Mahmut Şahin, Dilek Ural. Data on prevalence of dyslipidemia and lipid values in Turkey: Systematic review and meta-analysis of epidemiological studies on cardiovascular risk factors. Turk Kardiyol Dern Ars. 2018; 46(7): 556-574

Corresponding Author: Meral Kayıkçıoğlu, Türkiye
© Copyright 2018 Archives of the Turkish Society of Cardiology
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