ISSN 1016-5169 | E-ISSN 1308-4488
pdf
Proprotein convertase subtilisin/kexin type 9 (PCSK9) and inhibitors [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2014; 42(2): 56-67

Proprotein convertase subtilisin/kexin type 9 (PCSK9) and inhibitors

Ahmet Avcı, Kenan Demir, Bülent Behlül Altunkeser
Selcuk University Faculty of Medicine, Department of Cardiology, Konya, Turkey

Hypercholesterolemia is a major risk factor for atherosclerosis. Low-density lipoprotein cholesterol (LDLC) lowering drugs reduce cardiovascular morbidity and mortality. However, many individuals treated with statins do not achieve their target levels of LDL-C. So, there is great need for new drugs to reduce cholesterol in those patients who have not achieved target levels with statins as well as those who are statin intolerant. Proprotein convertase subtilisin/ kexin type 9 (PCSK9) is a novel agent, which plays an important role in the regulation of cholesterol metabolism. It increases degradation of the low-density lipoprotein receptor, modulates cholesterol metabolism, and transport. This review will address new therapeutic strategies targeting PCSK9, including monoclonal antibodies, small interfering RNAs, and other small molecule inhibitors.


How to cite this article
Ahmet Avcı, Kenan Demir, Bülent Behlül Altunkeser. Proprotein convertase subtilisin/kexin type 9 (PCSK9) and inhibitors. Turk Kardiyol Dern Ars. 2014; 42(2): 56-67

Corresponding Author: Ahmet Avcı, Türkiye
Manuscript Language: Turkish


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 Archives of the Turkish Society of Cardiology



Kare Publishing is a subsidiary of Kare Media.