Turk Kardiyol Dern Ars. 2005; 33(8): 452-459
The relationship between serum myeloperoxidase levels and major cardiovascular events in patients with acute coronary syndrome
, M.Kemal Erol1
, Ahmet Kızıltunç2
, Engin Bozkurt1
, H.Yekta Gürlertop112
OBJECTIVES This study was planned to assess the relationship between serum myeloperoxidase (MPO) levels and major cardiovascular events in patients with acute coronary syndrome.
STUDY DESIGN Serum MPO levels were measured by ELISA on admission of 243 consecutive patients with acute coronary syndrome (153 acute myocardial infarction, 90 unstable angina). Major cardiac events that occurred during hospitalization and 30-day follow-up period included recurrent angina, reinfarction, ventricular (ventricular tachycardia, ventricular fibrillation) and supraventricular (atrial fibrillation, supraventricular tachycardia) arrhythmias, complete atrioventricular block, clinical heart failure, and death. Correlations were sought between high (n=70, >350 µg/l) and low (n=173, ?350 µg/l) MPO levels and major events. Relative risks were estimated using the Cox proportional hazards regression model.
RESULTS The incidence of hypercholesterolemia was significantly higher in patients with high levels of MPO (p=0.008). A significant association was found between high levels of MPO and increased mortality risk during both hospitalization (hazard ratio-HR, 3.91; 95% CI 1.12-13.6; p=0.03) and 30-day follow-up period (HR 5.08, 95% CI 1.64-15.7; p=0.005). No significant differences were observed between patients with high and low MPO levels with respect to the development of arrhythmia, reinfarction, recurrent angina, and clinical heart failure (p>0.05).
CONCLUSION The results of this study demonstrate that elevated MPO levels predict death during hospital stay and 30-day follow-up period in patients with acute coronary syndrome.
Biological markers/blood; chest pain/enzymology; coronary disease/blood/enzymology; coronary thrombosis; inflammation mediators/blood; isoenzymes/blood; myocardial infarction; peroxidase/blood
How to cite this article
Şakir Arslan, M.Kemal Erol, Ahmet Kızıltunç, Engin Bozkurt, H.Yekta Gürlertop. The relationship between serum myeloperoxidase levels and major cardiovascular events in patients with acute coronary syndrome. Turk Kardiyol Dern Ars. 2005; 33(8): 452-459