Lipid Profile, Familial Hypercholesterolemia Prevalance, and 2-Year Cardiovascular Outcome Assessment in Acute Coronary Syndromes: A Real Life Data of A Retrospective Cohort [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. Ahead of Print: TKDA-07360 | DOI: 10.5543/tkda.2019.07360

Lipid Profile, Familial Hypercholesterolemia Prevalance, and 2-Year Cardiovascular Outcome Assessment in Acute Coronary Syndromes: A Real Life Data of A Retrospective Cohort

Meral Kayikcioglu1, BAHADIR ALAN2, Serdar Payzın2, Levent Hürkan Can2
1Ege University Medical School, Department Of Cardiology, Izmir
2Okan University Medical School, Department Of Cardiology, Istanbul

AIM
This retrospective study, based on real-life data, aimed to evaluate lipid profile and demographic, clinical, and laboratory features of patients with acute coronary syndrome (ACS) in a tertiary center and to determine mortality rates.

METHODS
Information including at least 2-year endpoint data after index ACS event was retrieved from hospital records. Patients without sufficient follow-up data were called by phone. Modified Dutch lipid network criteria were used to identify the presence of familial hypercholesterolaemia. Factors affecting mortality in the 2-year follow-up period were evaluated using Cox regression analysis.

RESULTS
A total of 985 ACS patients (215 females) between 21-93 years of age were included. Females were older and had lower smoking rate than males. In females, history of obesity and hypertension, diabetes rate, and TSH levels were higher than those in males. In 95.6% of the patients, lipid parameters were measured in hospital admission. No significant difference was observed between genders regarding dyslipidemia frequency. Familial hypercholesterolemia (FH) frequency was 7.6%. While the rate of lipid-lowering drug use was <20% at admission, was above 90% at discharge and decreased to 50% in the follow-up visits. Mortality rate in the ACS patients was 3.8% in the in-hospital period and 8.1% in the 2-year follow-up period.

CONCLUSION
Mortality rate in the ACS patients was 3.8% in the in-hospital period and 8.1% in the 2-year follow-up period. Hypercholesterolemia frequency was 89.5% and the rate of lipid-lowering drug use was insufficient. Secondary prevention after ACS cannot be adequately employed even in a tertiary center. FH frequency was 7.6% and those with FH were observed to have ACS at a younger age than those without.

Keywords: Acute coronary syndrome, Familial hypercholesterolemia, LDL-cholesterol, secondary prevention, mortality

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Corresponding Author: Meral Kayikcioglu, Türkiye
© Copyright 2019 Archives of the Turkish Society of Cardiology
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