The relationship between echocardiographic parameters and brain natriuretic peptide levels in acute and chronic mitral regurgitation [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2011; 39(3): 191-197 | DOI: 10.5543/tkda.2011.01273

The relationship between echocardiographic parameters and brain natriuretic peptide levels in acute and chronic mitral regurgitation

Ramazan Kargin1, Ozlem Esen3, Selcuk Pala1, Mustafa Akcakoyun1, Yunus Emiroglu1, Kursat Arslan1, Soe Moe Aung1, Irfan Barutcu2, Ali Metin Esen1, Nihal Ozdemir1
1Kartal-kosuyolu Heart And Research Hospital; Cardiolgy Department. Istanbul, Turkey
2Avicenna Hospital, Cardiology Department, Istanbul, Turkey
3Memorial Hospital, Cardiology Department, Istanbul, Turkey


OBJECTIVES
Plasma brain natriuretic peptide (BNP) level increases with symptoms and severity of mitral regurgitation (MR). We aimed to determine the relationship between plasma BNP levels and echocardiographic parameters in patients with acute and chronic MR.

STUDY DESIGN
The study included 55 patients (31 males, 24 females) with isolated moderate-to-severe MR. Of these, 31 patients had acute MR, and 24 patients had chronic MR. All the patients were assessed by transthoracic, transesophageal and Doppler echocardiography and plasma BNP levels were determined.

RESULTS
Clinical characteristics and functional capacity were similar in the two groups. Patients with acute MR had significantly higher left ventricular (LV) ejection fraction (EF) (p=0.001), and significantly lower LV end-systolic diameter (p=0.016), end-systolic volume (p=0.027), end-diastolic diameter (p=0.011), left atrial volume (LAV) (p=0.003), and plasma BNP levels (p=0.036). Effective regurgitation orifice area was also significantly higher in patients with acute MR (p=0.038). In multiple linear regression analysis, the natural logarithm of BNP was significantly correlated with E/Ea ratio (β=0.50, p=0.002) and LAV (β=0.38, p=0.015) in patients with acute MR, and with systolic pulmonary artery pressure (β=0.60, p=0.002) and EF (β=-0.36, p=0.039) in patients with chronic MR.

CONCLUSION
Although the echocardiographic degree of MR was more pronounced in patients with acute MR, serum BNP levels tended to be lower in this group. Correlation of serum BNP with E/Ea and LAV in this group may be an important finding.

Keywords: Echocardiography, mitral valve insufficiency; natriuretic peptide, brain; ventricular function, left

How to cite this article
Ramazan Kargin, Ozlem Esen, Selcuk Pala, Mustafa Akcakoyun, Yunus Emiroglu, Kursat Arslan, Soe Moe Aung, Irfan Barutcu, Ali Metin Esen, Nihal Ozdemir. The relationship between echocardiographic parameters and brain natriuretic peptide levels in acute and chronic mitral regurgitation. Turk Kardiyol Dern Ars. 2011; 39(3): 191-197

Corresponding Author: Ramazan Kargin, Türkiye
© Copyright 2018 Archives of the Turkish Society of Cardiology
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